Efficacy and Safety of Pembrolizumab (MK-3475) in Combination with Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)

Trial Identifier: 3475-676
Sponsor: MSD
Start Date: December 2018
Primary Completion Date: December 2025
Study Completion Date: November 2034

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For questions about your Trial Results Summary, please see Sponsor contact section within your Trial Results Summary.

Language Description
Protocol Plain Language Summary
Protocol Plain Language Summary

Trial Locations

Country Location
Australia, New South Wales St Leonards, New South Wales, Australia, 2065
Australia, New South Wales Wahroonga, New South Wales, Australia, 2076
Australia, Victoria Richmond, Victoria, Australia, 3121
Austria, Oberosterreich Linz, Oberosterreich, Austria, 4020
Austria, Salzburg Salzburg, Austria, 5020
Austria, Tirol Innsbruck, Tirol, Austria, 6020
Austria, Wien Vienna, Wien, Austria, 1090
Belgium, Antwerpen Edegem, Antwerpen, Belgium, 2650
Belgium, Namur Yvoir, Namur, Belgium, 5530
Belgium, Oost-Vlaanderen Aalst, Oost-Vlaanderen, Belgium, 9300
Belgium, Oost-Vlaanderen Gent, Oost-Vlaanderen, Belgium, 9000
Brazil, Ceara Fortaleza, Ceara, Brazil, 60135-237
Brazil, Parana Curitiba, Parana, Brazil, 81520060
Brazil, Sao Paulo Barretos, Sao Paulo, Brazil, 14784-400
Brazil, Sao Paulo Sao Paulo, Brazil, 01321-001
Brazil, Sao Paulo Sao Paulo, Brazil, 04014-002
Brazil, Sao Paulo Sao Paulo, Brazil, 01246-000
Canada, BC Abbotsford, BC, Canada, V2T 1X8
Canada, BC Victoria, BC, Canada, V8T 2C1
Canada, NB Moncton, NB, Canada, E1C 6Z8
Canada, ON Toronto, ON, Canada, M5G 2M9
Canada, QC Chicoutimi, QC, Canada, G7H 5H6
Canada, QC Montreal, QC, Canada, H1T 2M4
Canada, QC Quebec, QC, Canada, G1J 1Z4
Canada, QC Sherbrooke, QC, Canada, J1H 5N4
China, Beijing Beijing, China, 100142
China, Beijing Beijing, China, 100034
China, Beijing Beijing, China, 100021
China, Chongqing Chongqing, China, 400030
China, Fujian Xiamen, Fujian, China, 361003
China, Guangdong Guangzhou, Guangdong, China, 510060
China, Guangdong Guangzhou, Guangdong, China, 510120
China, Guangdong Guangzhou, Guangdong, China, 510289
China, Guangdong Shenzhen, Guangdong, China, 518020
China, Heilongjiang Harbin, Heilongjiang, China, 150081
China, Henan Zhengzhou, Henan, China, 450008
China, Hubei Wuhan, Hubei, China, 430000
China, Hubei Wuhan, Hubei, China, 430010
China, Hunan Changsha, Hunan, China, 410013
China, Jiangsu NanJing, Jiangsu, China, 210008
China, Jiangsu Suzhou, Jiangsu, China, 215004
China, Shaanxi xi'an, Shaanxi, China, 710061
China, Sichuan Cheng Du, Sichuan, China, 610041
China, Tianjin Tianjin, China, 300211
China, Zhejiang Hangzhou, Zhejiang, China, 310014
China, Zhejiang Wenzhou, Zhejiang, China, 325000
Colombia, Antioquia Medellín, Antioquia, Colombia, 050024
Colombia, Antioquia Rionegro, Antioquia, Colombia, 054047
Colombia, Cordoba Montería, Cordoba, Colombia, 230002
Colombia, Distrito Capital de Bogota Bogota, Distrito Capital de Bogota, Colombia, 111321
Colombia, Distrito Capital de Bogota Bogotá, Distrito Capital de Bogota, Colombia, 110221
Colombia, Risaralda Pereira, Risaralda, Colombia, 661001
Colombia, Valle del Cauca Cali, Valle del Cauca, Colombia, 76001
Colombia, Valle del Cauca Cali, Valle del Cauca, Colombia, 760042
Costa Rica, San Jose San Jose, Costa Rica, 10103
Costa Rica, San Jose San José, San Jose, Costa Rica, 10103
Finland, Pirkanmaa Tampere, Pirkanmaa, Finland, 33520
France, Bourgogne Dijon, Bourgogne, France, 21000
France, Hauts-de-Seine Suresnes, Hauts-de-Seine, France, 92150
France, Ille-et-Vilaine Rennes, Ille-et-Vilaine, France, 35000
France, Nord Lille, Nord, France, 59037
France, Seine-et-Marne Créteil, Seine-et-Marne, France, 94000
Germany, Bayern Munich, Bayern, Germany, 81675
Germany, Bayern Weiden in der Oberpfalz, Bayern, Germany, 92637
Germany, Bayern Wuerzburg, Bayern, Germany, 97080
Germany, Rheinland-Pfalz Trier, Rheinland-Pfalz, Germany, 54292
Germany, Thuringen Jena, Thuringen, Germany, 07747
Greece, Achaia Patra, Achaia, Greece, 265 04
Greece, Achaia Patras, Achaia, Greece, 264 43
Greece, Attiki Chaidari, Attiki, Greece, 124 62
Greece, Kentriki Makedonia Thessaloniki, Kentriki Makedonia, Greece, 54007
Greece, Thessalia Larissa, Thessalia, Greece, 411 10
Guatemala, Guatemala Guatemala, Guatemala, 01010
Guatemala, Guatemala Guatemala, Guatemala, 01015
Guatemala, Guatemala Guatemala City, Guatemala, Guatemala, 01010
Hungary, Baranya Pécs, Baranya, Hungary, 7621
Hungary, Budapest Budapest, Hungary, 1082
Hungary, Csongrad Szeged, Csongrad, Hungary, 6725
Hungary, Debrecen Debrecen, Hungary, 4032
Italy, Abruzzo Chieti, Abruzzo, Italy, 66100
Italy, Arezzo Arezzo, Italy, 52100
Italy, Bari Bari, Italy, 70124
Italy, Genova Genova, Italy, 16132
Italy, Milano Milan, Milano, Italy, 20133
Italy, Milano Milano, Italy, 20132
Italy, Palermo Palermo, Italy, 90123
Italy, Piemonte Torino, Piemonte, Italy, 10128
Italy, Roma Roma, Italy, 00168
Italy, Toscana Firenze, Toscana, Italy, 50134
Italy, Trentino-Sudtirol Bolzano, Trentino-Sudtirol, Italy, 39100
Italy, Verona Verona, Italy, 37126
Japan, Aomori Hirosaki, Aomori, Japan, 036-8563
Japan, Chiba Chiba, Japan, 260-8717
Japan, Ehime Toon, Ehime, Japan, 791-0295
Japan, Fukuoka Fukuoka, Japan, 812-0033
Japan, Ibaraki Tsukuba, Ibaraki, Japan, 305-8576
Japan, Kanagawa Kawasaki, Kanagawa, Japan, 216-8511
Japan, Kanagawa Sagamihara, Kanagawa, Japan, 252-0375
Japan, Kanagawa Yokosuka, Kanagawa, Japan, 238-8558
Japan, Nara Kashihara, Nara, Japan, 634-8522
Japan, Osaka Osaka, Japan, 545-8586
Japan, Osaka Osaka, Japan, 541-8567
Japan, Shizuoka Hamamatsu, Shizuoka, Japan, 431-3192
Japan, Tokyo Tokyo, Japan, 160-8582
Japan, Tokyo Tokyo, Japan, 113-8519
Korea, Republic of, Seoul Seoul, Korea, Republic of, 02841
Korea, Republic of, Seoul Seoul, Korea, Republic of, 03080
Korea, Republic of, Seoul Seoul, Korea, Republic of, 06351
Korea, Republic of, Seoul Songpagu, Seoul, Korea, Republic of, 05505
Malaysia, Kuala Lumpur Kuala Lumpur, Malaysia, 59100
Netherlands, Limburg Maastricht, Limburg, Netherlands, 6229 HX
Netherlands, Utrecht Utrecht, Netherlands, 3584 CX
Netherlands, Zuid-Holland Rotterdam, Zuid-Holland, Netherlands, 3015 GD
Norway, Akershus Lorenskog, Akershus, Norway, 1478
Norway, Rogaland Stavanger, Rogaland, Norway, 4011
Peru, Lima La Victoria, Lima, Peru, 15033
Peru, Lima Lima, Peru, 15076
Peru, Muni Metro de Lima Lima, Muni Metro de Lima, Peru, 15036
Poland, Dolnoslaskie Wroclaw, Dolnoslaskie, Poland, 50-556
Poland, Kujawsko-pomorskie Torun, Kujawsko-pomorskie, Poland, 87-100
Poland, Malopolskie Krakow, Malopolskie, Poland, 30-510
Poland, Malopolskie Tarnow, Malopolskie, Poland, 33-100
Poland, Mazowieckie Siedlce, Mazowieckie, Poland, 08-110
Poland, Mazowieckie Warsaw, Mazowieckie, Poland, 02-798
Poland, Mazowieckie Warszawa, Mazowieckie, Poland, 01-748
Poland, Podkarpackie Przemysl, Podkarpackie, Poland, 37-700
Poland, Pomorskie Koscierzyna, Pomorskie, Poland, 83-400
Poland, Pomorskie Slupsk, Pomorskie, Poland, 76-200
Poland, Slaskie Rybnik, Slaskie, Poland, 44-200
Poland, Wielkopolskie Poznan, Wielkopolskie, Poland, 61-731
Portugal, Braga Braga, Portugal, 4710-243
Portugal, Coimbra Coimbra, Portugal, 3000-075
Portugal, Lisboa Lisboa, Portugal, 1998-018
Portugal, Lisboa Lisboa, Portugal, 1099-023
Portugal, Lisboa Lisbon, Lisboa, Portugal, 1649-035
Portugal, Porto Porto, Portugal, 4200-072
Spain, Barcelona Barcelona, Spain, 08025
Spain, La Coruna Lugo, La Coruna, Spain, 27003
Spain, Madrid Madrid, Spain, 28027
Spain, Madrid Madrid, Spain, 28034
Spain, Madrid Madrid, Spain, 28033
Spain, Madrid Madrid, Spain, 28046
Spain, Madrid MADRID, Madrid, Spain, 28007
Spain, Madrid, Comunidad de Pozuelo de Alarcon, Madrid, Comunidad de, Spain, 28223
Spain, Navarra Pamplona, Navarra, Spain, 31008
Spain, Valencia Valencia, Spain, 46026
Switzerland, Basel-Stadt Basel, Basel-Stadt, Switzerland, 4031
Switzerland, Geneve Geneve, Switzerland, 1205
Switzerland, Zurich Zurich, Switzerland, 8091
Turkey, Ankara Ankara, Turkey, 06590
Turkey, Eskisehir Eskisehir, Turkey, 26480
Turkey, Istanbul Istanbul, Turkey, 34722
Turkey, Istanbul Istanbul, Turkey, 34385
Turkey, Izmir Izmir, Turkey, 35340
Turkey, Konya Konya, Turkey, 42000
United Kingdom, Highland Inverness, Highland, United Kingdom, IV2 3UJ
United Kingdom, London, City of London, London, City of, United Kingdom, EC1A 7BE
United Kingdom, London, City of London, London, City of, United Kingdom, SW17 0QT
United States, AK Anchorage, AK, United States, 99503
United States, AZ Phoenix, AZ, United States, 85054
United States, AZ Tucson, AZ, United States, 85704
United States, CA Los Angeles, CA, United States, 90095
United States, CA Orange, CA, United States, 92868
United States, CA Torrance, CA, United States, 90505
United States, CO Lakewood, CO, United States, 80228
United States, FL Hialeah, FL, United States, 33016
United States, FL Jacksonville, FL, United States, 32224
United States, FL Miami, FL, United States, 33136
United States, FL Pensacola, FL, United States, 32503
United States, GA Atlanta, GA, United States, 30322
United States, GA Roswell, GA, United States, 30076
United States, IL Chicago, IL, United States, 60611
United States, KS Wichita, KS, United States, 67226
United States, LA Shreveport, LA, United States, 71106
United States, MI Detroit, MI, United States, 48202
United States, MI Troy, MI, United States, 48084
United States, NJ Brick, NJ, United States, 08724
United States, NJ Morristown, NJ, United States, 07960
United States, NJ New Brunswick, NJ, United States, 08903
United States, NY Albany, NY, United States, 12208
United States, NY Lake Success, NY, United States, 11042
United States, NY New York, NY, United States, 10016
United States, NY New York, NY, United States, 10010
United States, NY Syracuse, NY, United States, 13210
United States, OH Cincinnati, OH, United States, 45212
United States, OH Cleveland, OH, United States, 44106
United States, OH Columbus, OH, United States, 43210
United States, OR Portland, OR, United States, 97210
United States, OR Springfield, OR, United States, 97477
United States, PA Bala Cynwyd, PA, United States, 19004
United States, PA Lancaster, PA, United States, 17604
United States, PA Philadelphia, PA, United States, 19104
United States, PR Ponce, PR, United States, 00716
United States, PR Ponce, PR, United States, 00717
United States, SC Myrtle Beach, SC, United States, 29572
United States, TN Nashville, TN, United States, 37209
United States, TX Dallas, TX, United States, 75231
United States, TX Dallas, TX, United States, 75390
United States, TX Fort Worth, TX, United States, 76104
United States, TX Houston, TX, United States, 77027
United States, TX Plano, TX, United States, 75093
United States, TX San Antonio, TX, United States, 78229
United States, VA Virginia Beach, VA, United States, 23462
United States, VT Burlington, VT, United States, 05401