A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) post one NHA (MK-5684-004)

Trial Identifier: 5684-004
Sponsor: MSD
Collaborator:
Orion Corporation
Start Date: December 2023
Primary Completion Date: May 2028
Study Completion Date: December 2030
Condition: Prostate Cancer

Available Languages

For questions about your Trial Results Summary, please see Sponsor contact section within your Trial Results Summary.

Language Description
Protocol Plain Language Summary - English

Trial Locations

Country Location
Australia, New South Wales Macquarie University, New South Wales, Australia, 2109
Australia, New South Wales Westmead, New South Wales, Australia, 2145
Australia, Queensland Brisbane, Queensland, Australia, 4029
Australia, Victoria Clayton, Victoria, Australia, 3168
Australia, Victoria Melbourne, Victoria, Australia, 3000
Brazil, Bahia Salvador, Bahia, Brazil, 40415-006
Brazil, Ceara Fortaleza, Ceara, Brazil, 60336-232
Brazil, Espirito Santo Vitória, Espirito Santo, Brazil, 29043-260
Brazil, Maranhao Sao Luis, Maranhao, Brazil, 65060-645
Brazil, Minas Gerais Belo Horizonte, Minas Gerais, Brazil, 30380-472
Brazil, Minas Gerais Uberaba, Minas Gerais, Brazil, 38025-350
Brazil, Parana Curitiba, Parana, Brazil, 80510-130
Brazil, Parana Curitiba, Parana, Brazil, 80730-150
Brazil, Rio Grande do Sul Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
Brazil, Santa Catarina Itajaí, Santa Catarina, Brazil, 88301-220
Brazil, Sao Paulo Bragança Paulista, Sao Paulo, Brazil, 12916-542
Brazil, Sao Paulo São José do Rio Preto, Sao Paulo, Brazil, 15090-000
Brazil, Sao Paulo Sao Paulo, Brazil, 01321-001
Brazil, Sao Paulo Taubaté, Sao Paulo, Brazil, 12030-200
Canada, AB Edmonton, AB, Canada, T6G 1Z2
Canada, ON Mississauga, ON, Canada, L5M 2N1
Canada, ON Ottawa, ON, Canada, K1H 8L6
Canada, ON Toronto, ON, Canada, M4N 3M5
Canada, QC Montréal, QC, Canada, H2X 3E4
Canada, QC Quebec City, QC, Canada, G1J 1Z4
Chile, Araucania Temuco, Araucania, Chile, 4810218
Chile, Maule Talca, Maule, Chile, 3465584
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 8420383
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 7500921
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 8330024
Chile, Valparaiso Viña del Mar, Valparaiso, Chile, 2520598
China, Anhui Hefei, Anhui, China, 230000
China, Beijing Beijing, China, 100853
China, Beijing Beijing, China, 100034
China, Beijing Beijing, China, 100142
China, Beijing Beijing, China, 130021
China, Chongqing Chongqing, China, 400030
China, Chongqing Chongqing, China, 400038
China, Fujian Fuzhou, Fujian, China, 350005
China, Guangdong Guangzhou, Guangdong, China, 510700
China, Guangdong Guangzhou, Guangdong, China, 510030
China, Hubei Wuhan, Hubei, China, 430079
China, Hubei Wuhan, Hubei, China, 430000
China, Hubei Wuhan, Hubei, China, 430014
China, Hunan Changsha, Hunan, China, 410013
China, Jiangsu NanJing, Jiangsu, China, 210008
China, Jiangsu Nantong, Jiangsu, China, 226361
China, Jiangsu Wuxi, Jiangsu, China, 214023
China, Shaanxi Xi an, Shaanxi, China, 710061
China, Shaanxi Xi'an, Shaanxi, China, 710004
China, Shandong Yantai, Shandong, China, 264099
China, Shanghai Shanghai, China, 200041
China, Shanghai Shanghai, China, 200001
China, Sichuan Cheng Du, Sichuan, China, 610041
China, Sichuan Nanchong, Sichuan, China, 500643
China, Tianjin Tianjin, China, 300211
China, Xinjiang Urumqi, Xinjiang, China, 830000
China, Yunnan Kunming, Yunnan, China, 650107
China, Zhejiang Hangzhou, Zhejiang, China, 310014
China, Zhejiang Jiaxing, Zhejiang, China, 314001
China, Zhejiang Ningbo, Zhejiang, China, 315010
China, Zhejiang Wenzhou, Zhejiang, China, 325015
Colombia, Cesar Valledupar, Cesar, Colombia, 200001
Colombia, Cordoba Monteria, Cordoba, Colombia, 230002
Colombia, Distrito Capital de Bogota Bogota, Distrito Capital de Bogota, Colombia, 111321
Colombia, Distrito Capital de Bogota Bogota, Distrito Capital de Bogota, Colombia, 110121
Colombia, Santander Piedecuesta, Santander, Colombia, 681017
Colombia, Valle del Cauca Cali, Valle del Cauca, Colombia, 760042
Colombia, Valle del Cauca Cali, Valle del Cauca, Colombia, 760032
Costa Rica, San Jose San Jose, Costa Rica, 10103
Costa Rica, San Jose San José, San Jose, Costa Rica, 10103
Costa Rica, San Jose Santa Ana, San Jose, Costa Rica, 10903
Czech Republic, Brno-mesto Brno, Brno-mesto, Czech Republic, 656 53
Czech Republic, Jihomoravsky kraj Brno, Jihomoravsky kraj, Czech Republic, 602 00
Czech Republic, Liberecky kraj Liberec, Liberecky kraj, Czech Republic, 460 01
Czech Republic, Olomouc Olomouc, Czech Republic, 77900
Czech Republic, Praha 2 Praha 2, Czech Republic, 12808
Czech Republic, Praha 5 Praha, Praha 5, Czech Republic, 150 06
Estonia, Harjumaa Tallinn, Harjumaa, Estonia, 13419
Estonia, Harjumaa Tallinn, Harjumaa, Estonia, 11314
Estonia, Parnumaa Pärnu, Parnumaa, Estonia, 80010
Estonia, Tartumaa Tartu, Tartumaa, Estonia, 50406
France, Alsace Strasbourg, Alsace, France, 67200
France, Aquitaine BORDEAUX, Aquitaine, France, 33076
France, Finistere BREST, Finistere, France, 29609
France, Haute-Garonne Quint-Fonsegrives, Haute-Garonne, France, 31130
France, Hauts-de-Seine Suresnes, Hauts-de-Seine, France, 92150
France, Nord-Pas-de-Calais Lille, Nord-Pas-de-Calais, France, 59000
France, Paris Paris, France, 75014
France, Puy-de-Dome Clermont-Ferrand, Puy-de-Dome, France, 63003
France, Rhone-Alpes Lyon CEDEX08, Rhone-Alpes, France, 69373
France, Val-de-Marne villejuif, Val-de-Marne, France, 94800
France, Vaucluse Avignon, Vaucluse, France, 84000
Germany, Baden-Wurttemberg Freiburg, Baden-Wurttemberg, Germany, 79106
Germany, Baden-Wurttemberg Heidelberg, Baden-Wurttemberg, Germany, 69120
Germany, Baden-Wurttemberg Nürtingen, Baden-Wurttemberg, Germany, 72622
Germany, Bayern Munich, Bayern, Germany, 81675
Germany, Bayern Regensburg, Bayern, Germany, 93053
Germany, Berlin Berlin, Germany, 10967
Germany, Berlin Berlin, Germany, 10117
Germany, Hessen Marburg, Hessen, Germany, 35043
Germany, Niedersachsen Göttingen, Niedersachsen, Germany, 37075
Germany, Nordrhein-Westfalen Bergisch Gladbach, Nordrhein-Westfalen, Germany, 51465
Germany, Nordrhein-Westfalen Köln, Nordrhein-Westfalen, Germany, 50937
Germany, Sachsen Dresden, Sachsen, Germany, 01307
Greece, Achaia PATRAS, Achaia, Greece, 26504
Greece, Attiki Athens, Attiki, Greece, 115 28
Greece, Attiki Chaidari, Attiki, Greece, 124 62
Guatemala, Guatemala Ciudad de Guatemala, Guatemala, Guatemala, 01010
Guatemala, Guatemala Guatemala, Guatemala, 01010
Guatemala, Guatemala Guatemala, Guatemala, 01009
Guatemala, Guatemala Guatemala, Guatemala, 01015
Hong Kong, N/A Central, N/A, Hong Kong, 999077
Hong Kong, N/A Hong Kong, N/A, Hong Kong, N/A
Hungary, Borsod-Abauj-Zemplen Miskolc, Borsod-Abauj-Zemplen, Hungary, 3526
Hungary, Debrecen Debrecen, Hungary, 4032
Hungary, Nograd Salgótarján, Nograd, Hungary, 3100
Hungary, Pest Budapest, Pest, Hungary, 1122
Ireland, Dublin Dublin, Ireland, D24 NR0A
Ireland, Dublin Dublin 04, Dublin, Ireland, D04 T6F4
Israel, N/A Afula, N/A, Israel, 1834111
Israel, N/A Haifa, N/A, Israel, 3109601
Israel, N/A Jerusalem, N/A, Israel, 9112001
Israel, N/A Jerusalem, N/A, Israel, 9103102
Israel, N/A Kfar Saba, N/A, Israel, 4428164
Israel, N/A Petah Tikva, N/A, Israel, 4941492
Israel, N/A Ramat Gan, N/A, Israel, 5265601
Israel, N/A Tel Aviv, N/A, Israel, 6423906
Italy, Catania Catania, Italy, 95126
Italy, Emilia-Romagna Meldola, Emilia-Romagna, Italy, 47014
Italy, Foggia Foggia, Italy, 71100
Italy, Lombardia Milan, Lombardia, Italy, 20133
Italy, Milano Milano, Italy, 20132
Italy, Terni Terni, Italy, 05100
Japan, Akita Akita, Japan, 010-8543
Japan, Chiba Sakura, Chiba, Japan, 285-8741
Japan, Fukui Eiheiji-cho,Yoshida-gun, Fukui, Japan, 910-1193
Japan, Fukuoka Fukuoka, Japan, 812-8582
Japan, Fukuoka Kitakyushu, Fukuoka, Japan, 807-8556
Japan, Fukushima Fukushima, Japan, 960-1295
Japan, Gifu Gifu, Japan, 501-1112
Japan, Hiroshima Hiroshima, Japan, 734-8551
Japan, Hokkaido Sapporo, Hokkaido, Japan, 060-8543
Japan, Hokkaido Sapporo, Hokkaido, Japan, 060-8648
Japan, Hyogo Kobe, Hyogo, Japan, 650-0017
Japan, Ishikawa Uchinada, Ishikawa, Japan, 920-0265
Japan, Kagawa Kita, Kagawa, Japan, 761-0701
Japan, Kagoshima Kagoshima, Japan, 890-8520
Japan, Kanagawa Yokohama, Kanagawa, Japan, 232-0024
Japan, Kumamoto Kumamoto, Japan, 860-0008
Japan, Mie Tsu, Mie, Japan, 514-8507
Japan, Miyazaki Miyazaki, Japan, 880-8510
Japan, Miyazaki Miyazaki, Japan, 889-1692
Japan, Nagano Nagano, Japan, 381-8551
Japan, Nagasaki Ōmura, Nagasaki, Japan, 856-8562
Japan, Nara Kashihara, Nara, Japan, 634-8522
Japan, Oita Oita, Japan, 870-0263
Japan, Okinawa Shimajiri, Okinawa, Japan, 901-0417
Japan, Osaka Hirakata, Osaka, Japan, 573-1191
Japan, Osaka Sakai, Osaka, Japan, 599-8247
Japan, Osaka Suita, Osaka, Japan, 565-0871
Japan, Saga Saga-shi, Saga, Japan, 840-8571
Japan, Tokyo Itabashiku, Tokyo, Japan, 173-8610
Japan, Tokyo Minato, Tokyo, Japan, 105-8471
Korea, Republic of, Kyonggi-do Goyang-si, Kyonggi-do, Korea, Republic of, 10408
Korea, Republic of, Kyonggi-do Seongnam, Kyonggi-do, Korea, Republic of, 13620
Korea, Republic of, Kyongsangbuk-do Buk-gu, Kyongsangbuk-do, Korea, Republic of, 41404
Korea, Republic of, Kyongsangnam-do Pusan, Kyongsangnam-do, Korea, Republic of, 50612
Korea, Republic of, Seoul Seoul, Korea, Republic of, 03080
Korea, Republic of, Seoul Seoul, Korea, Republic of, 06591
Latvia, Liepaja Liepaja, Latvia, LV3414
Latvia, Riga Riga, Latvia, LV-1002
Lithuania, Kauno apskritis Kaunas, Kauno apskritis, Lithuania, 50161
Lithuania, Vilniaus miestas Vilnius, Vilniaus miestas, Lithuania, 08660
Malaysia, Johor Johor Bahru, Johor, Malaysia, 81100
Malaysia, Kuala Lumpur Kuala Lumpur, Malaysia, 50586
Malaysia, Kuala Lumpur Lembah Pantai, Kuala Lumpur, Malaysia, 59100
Malaysia, Sarawak Kuching, Sarawak, Malaysia, 93586
Malaysia, Wilayah Persekutuan Putrajaya PUTRAJAYA, Wilayah Persekutuan Putrajaya, Malaysia, 62250
Mexico, Distrito Federal Ciudad de México, Distrito Federal, Mexico, 11810
Mexico, Distrito Federal Ciudad de México, Distrito Federal, Mexico, 03100
Mexico, Distrito Federal Tlalpan, Distrito Federal, Mexico, 14308
Mexico, Jalisco Guadalajara, Jalisco, Mexico, 44630
Mexico, Nuevo Leon Monterrey, Nuevo Leon, Mexico, 64718
Mexico, Nuevo Leon Monterrey, Nuevo Leon, Mexico, 64460
Mexico, Oaxaca Oaxaca de Juarez, Oaxaca, Mexico, 68020
New Zealand, Auckland Auckland, New Zealand, 1023
New Zealand, Otago Dunedin, Otago, New Zealand, 9016
Peru, Lima Lima, Peru, 15036
Peru, Lima LIMA, Lima, Peru, 15038
Portugal, Braga Braga, Portugal, 4710-243
Portugal, Lisboa Alcabideche, Lisboa, Portugal, 2755-009
Portugal, Lisboa Lisboa, Portugal, 1350-352
Portugal, Lisboa Lisboa, Portugal, 1649-035
Portugal, Porto Porto, Portugal, 4099-001
Portugal, Porto Vila Nova de Gaia, Porto, Portugal, 4434-502
Romania, Bucuresti București, Bucuresti, Romania, 011461
Romania, Cluj Cluj-Napoca, Cluj, Romania, 400015
Romania, Cluj Florești, Cluj, Romania, 407280
Romania, Dolj Craiova, Dolj, Romania, 200746
Singapore, Central Singapore Singapore, Central Singapore, Singapore, 169608
Singapore, Central Singapore Singapore, Central Singapore, Singapore, 119074
Singapore, Central Singapore Singapore, Central Singapore, Singapore, 168583
Singapore, Central Singapore Singapore, Central Singapore, Singapore, 308433
Slovakia, Nitriansky kraj Nitra, Nitriansky kraj, Slovakia, 949 01
Slovakia, Trenciansky kraj Trencin, Trenciansky kraj, Slovakia, 911 01
South Africa, Eastern Cape Port Elizabeth, Eastern Cape, South Africa, 6055
South Africa, Gauteng Johannesburg, Gauteng, South Africa, 2193
South Africa, Gauteng Pretoria, Gauteng, South Africa, 0040
South Africa, Gauteng Pretoria, Gauteng, South Africa, 0181
South Africa, Gauteng Pretoria, Gauteng, South Africa, 0084
South Africa, Western Cape Cape Town, Western Cape, South Africa, 7570
Spain, Barcelona Sabadell, Barcelona, Spain, 08208
Spain, Burgos Burgos, Spain, 09006
Spain, Cataluna Barcelona, Cataluna, Spain, 08036
Spain, Gerona Girona, Gerona, Spain, 17007
Spain, La Coruna A Coruna, La Coruna, Spain, 15006
Spain, Las Palmas Las Palmas de Gran Canaria, Las Palmas, Spain, 35016
Spain, Madrid Pozuelo de Alarcon, Madrid, Spain, 28223
Spain, Malaga Malaga, Spain, 29004
Sweden, Stockholms lan Stockholm, Stockholms lan, Sweden, 171 64
Sweden, Uppsala lan Uppsala, Uppsala lan, Sweden, 751 85
Taiwan, Kaohsiung Kaohsiung, Taiwan, 83301
Taiwan, Kaohsiung Kaohsiung, Taiwan, 81362
Taiwan, Taichung Taichung, Taiwan, 40447
Taiwan, Taichung Taichung, Taiwan, 40705
Taiwan, Tainan Tainan City, Tainan, Taiwan, 71004
Taiwan, Taipei Taipei, Taiwan, 112
Taiwan, Taoyuan Taoyuan, Taiwan, 333
Thailand, Chiang Mai Muang, Chiang Mai, Thailand, 50200
Thailand, Khon Kaen Muang, Khon Kaen, Thailand, 40002
Thailand, Krung Thep Maha Nakhon Bangkok, Krung Thep Maha Nakhon, Thailand, 10330
Thailand, Krung Thep Maha Nakhon Bangkok, Krung Thep Maha Nakhon, Thailand, 10700
Thailand, Songkhla Hatyai, Songkhla, Thailand, 90110
Turkey, Adana Adana, Turkey, 01250
Turkey, Ankara Ankara, Turkey, 06230
Turkey, Ankara Ankara, Turkey, 06800
Turkey, Istanbul Istanbul, Turkey, 34668
Turkey, Istanbul Istanbul, Turkey, 34722
Turkey, Istanbul Istanbul, Turkey, 34147
Turkey, Istanbul Istanbul, Turkey, 34010
Turkey, Izmir Izmir, Turkey, 35100
Turkey, Samsun Samsun, Turkey, 55200
United Kingdom, Cambridgeshire Cambridge, Cambridgeshire, United Kingdom, CB2 2QQ
United Kingdom, Derbyshire Derby, Derbyshire, United Kingdom, DE22 3NE
United Kingdom, Devon Torquay, Devon, United Kingdom, TQ2 7AA
United Kingdom, England Northwood, England, United Kingdom, HA6 2RN
United Kingdom, England Truro, England, United Kingdom, TR1 3LJ
United Kingdom, Glasgow City Glasgow, Glasgow City, United Kingdom, G12 0YN
United Kingdom, Hammersmith and Fulham london, Hammersmith and Fulham, United Kingdom, W6 8RF
United Kingdom, London, City of London, London, City of, United Kingdom, NW1 2PG
United Kingdom, London, City of London, London, City of, United Kingdom, SW17 0QT
United Kingdom, London, City of London, London, City of, United Kingdom, SE1 9RT
United Kingdom, Manchester manchester, Manchester, United Kingdom, m20 4bx
United Kingdom, Oxfordshire Oxford, Oxfordshire, United Kingdom, OX4 6LB
United Kingdom, Windsor and Maidenhead Windsor, Windsor and Maidenhead, United Kingdom, SL4 3HD
United States, AZ Tucson, AZ, United States, 85719
United States, CA Los Angeles, CA, United States, 90404
United States, CA Orange, CA, United States, 92868
United States, CA Palo Alto, CA, United States, 94304
United States, CA Redlands, CA, United States, 92373
United States, CA Riverside, CA, United States, 92505
United States, CA Sacramento, CA, United States, 95817
United States, CA San Francisco, CA, United States, 94121
United States, CA Vallejo, CA, United States, 94589
United States, CO Aurora, CO, United States, 80045
United States, CO Highlands Ranch, CO, United States, 80129
United States, CO Lakewood, CO, United States, 80228
United States, CO Lone Tree, CO, United States, 80124
United States, CT New Haven, CT, United States, 06510
United States, DC Washington, DC, United States, 20010
United States, FL Fort Myers, FL, United States, 33901
United States, FL Miami Beach, FL, United States, 33140
United States, FL Pembroke Pines, FL, United States, 33028
United States, GA Atlanta, GA, United States, 30342
United States, IL Elmhurst, IL, United States, 60126
United States, IL Naperville, IL, United States, 60540
United States, IL Peoria, IL, United States, 61615
United States, IN Carmel, IN, United States, 46032
United States, KY Lexington, KY, United States, 40536
United States, MD Baltimore, MD, United States, 21201
United States, MD Towson, MD, United States, 21204
United States, MI Detroit, MI, United States, 48202
United States, MI Grand Rapids, MI, United States, 49503
United States, MN Saint Louis Park, MN, United States, 55426
United States, MN Saint Paul, MN, United States, 55101
United States, MT Billings, MT, United States, 59102
United States, NE Omaha, NE, United States, 68130
United States, NJ New Brunswick, NJ, United States, 08901
United States, NV Las Vegas, NV, United States, 89102
United States, NV Las Vegas, NV, United States, 89148
United States, NY Syracuse, NY, United States, 13210
United States, OH Cleveland, OH, United States, 44106
United States, OH Gahanna, OH, United States, 43230
United States, OH Zanesville, OH, United States, 43701
United States, PA Bala Cynwyd, PA, United States, 19004
United States, PA Philadelphia, PA, United States, 19111
United States, PR Ponce, PR, United States, 00717
United States, PR Ponce, PR, United States, 00716
United States, PR San Juan, PR, United States, 00909
United States, SC Charleston, SC, United States, 29401
United States, SD Pierre, SD, United States, 57501
United States, SD Sioux Falls, SD, United States, 57105
United States, SD Yankton, SD, United States, 57078
United States, TN Germantown, TN, United States, 38138
United States, TX Austin, TX, United States, 78731
United States, TX Dallas, TX, United States, 75246
United States, TX Houston, TX, United States, 77024
United States, VA Charlottesville, VA, United States, 22908
United States, VA Fairfax, VA, United States, 22031
United States, VA Richmond, VA, United States, 23219
United States, VA Roanoke, VA, United States, 24014
United States, WA Spokane, WA, United States, 99202
United States, WA Vancouver, WA, United States, 98684
United States, WI MILWAUKEE, WI, United States, 53226