Study of Pembrolizumab (MK-3475) Versus Placebo in Combination with Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2–) Breast Cancer (MK-3475-756/KEYNOTE-756)

Trial Identifier: 3475-756
Sponsor: MSD
Start Date: December 2018
Primary Completion Date: January 2031
Study Completion Date: January 2031
Condition: Breast Cancer

Available Languages

For questions about your Trial Results Summary, please see Sponsor contact section within your Trial Results Summary.

Language Description
Protocol Plain Language Summary - English

Trial Locations

Country Location
Australia, New South Wales Camperdown, New South Wales, Australia, 2050
Australia, New South Wales Sydney, New South Wales, Australia, 2065
Australia, New South Wales Sydney, New South Wales, Australia, 2145
Australia, Queensland South Brisbane, Queensland, Australia, 4101
Australia, Victoria Frankston, Victoria, Australia, 3199
Australia, Victoria Melbourne, Victoria, Australia, 3000
Belgium, Antwerpen Bonheiden, Antwerpen, Belgium, 2820
Belgium, Antwerpen Edegem, Antwerpen, Belgium, 2650
Belgium, Bruxelles-Capitale, Region de Anderlecht, Bruxelles-Capitale, Region de, Belgium, 1070
Belgium, Bruxelles-Capitale, Region de Brussels, Bruxelles-Capitale, Region de, Belgium, 1200
Belgium, Liege Liège, Liege, Belgium, 4000
Belgium, Limburg Hasselt, Limburg, Belgium, 3500
Belgium, Namur Yvoir, Namur, Belgium, 5530
Belgium, Oost-Vlaanderen Gent, Oost-Vlaanderen, Belgium, 9000
Belgium, Vlaams-Brabant Leuven, Vlaams-Brabant, Belgium, 3000
Belgium, West-Vlaanderen Kortrijk, West-Vlaanderen, Belgium, 8500
Brazil, Goias Goiania, Goias, Brazil, 74605-070
Brazil, Rio de Janeiro Rio de Janeiro, Brazil, 20560-120
Brazil, Rio Grande do Sul Ijui, Rio Grande do Sul, Brazil, 98700-000
Brazil, Rio Grande do Sul Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
Brazil, Rio Grande do Sul Porto Alegre, Rio Grande do Sul, Brazil, 90035-001
Brazil, Santa Catarina Florianopolis, Santa Catarina, Brazil, 88034-000
Brazil, Santa Catarina Itajai, Santa Catarina, Brazil, 88301-220
Brazil, Sao Paulo Sao Paulo, Brazil, 01317-001
Brazil, Sao Paulo Sao Paulo, Brazil, 01246-000
Brazil, Sao Paulo São Paulo, Sao Paulo, Brazil, 04014-002
Canada, AB Edmonton, AB, Canada, T6G 1Z2
Canada, BC Vancouver, BC, Canada, V5Z 4E6
Canada, ON Toronto, ON, Canada, M5G 2M9
Canada, QC Greenfield Park, QC, Canada, J4V 2H1
Canada, QC Montreal, QC, Canada, H3T 1E2
Canada, QC Montreal, QC, Canada, H1T 2M4
Canada, QC Montreal, QC, Canada, H2X 3E4
Canada, QC Quebec, QC, Canada, G1S 4L8
Canada, QC Trois-Rivières, QC, Canada, G8Z 3R9
China, Anhui Heifei, Anhui, China, 230001
China, Anhui Shanghai, Anhui, China, 200025
China, Beijing Beijing, China, 100021
China, Fujian Fuzhou Fujian, Fujian, China, 350001
China, Guangdong Guangzhou, Guangdong, China, 510289
China, Hebei Shijia Zhuang, Hebei, China, 050019
China, Heilongjiang Harbin, Heilongjiang, China, 150081
China, Henan Zhengzhou, Henan, China, 450008
China, Hubei Wuhan, Hubei, China, 430079
China, Hunan Changsha, Hunan, China, 410006
China, Jiangsu Hangzhou, Jiangsu, China, 310003
China, Jilin Changchun, Jilin, China, 130021
China, Shanghai Shanghai, China, 200032
China, Shanxi Xi an, Shanxi, China, 710061
China, Tianjin Tianjin, China, 300060
China, Xinjiang Urumqi, Xinjiang, China, 830000
China, Zhejiang Hangzhou, Zhejiang, China, 310022
China, Zhejiang Hangzhou, Zhejiang, China, 310014
Colombia, Antioquia medellin, Antioquia, Colombia, 050030
Colombia, Antioquia Medellin, Antioquia, Colombia, 050030
Colombia, Atlantico Barranquilla, Atlantico, Colombia, 080020
Colombia, Cordoba Monteria, Cordoba, Colombia, 230001
Colombia, Distrito Capital de Bogota Bogota, Distrito Capital de Bogota, Colombia, 110221
Colombia, Distrito Capital de Bogota Bogota, Distrito Capital de Bogota, Colombia, 111221
Colombia, Valle del Cauca Cali, Valle del Cauca, Colombia, 760042
Costa Rica, San Jose Santa Ana, San Jose, Costa Rica, 10903
France, Calvados Caen, Calvados, France, 14000
France, Cote-d Or Dijon, Cote-d Or, France, 21079
France, Haute-Garonne Toulouse, Haute-Garonne, France, 31059
France, Hauts-de-Seine Saint-Cloud, Hauts-de-Seine, France, 92210
France, Herault Montpellier, Herault, France, 34070
France, Moselle Metz, Moselle, France, 57085
France, Nord-Pas-de-Calais Lille, Nord-Pas-de-Calais, France, 59000
France, Paris Paris, France, 75005
France, Paris Paris, France, 75010
France, Paris Paris, France, 75020
France, Provence-Alpes-Cote-d Azur Avignon, Provence-Alpes-Cote-d Azur, France, 84918
France, Puy-de-Dome Clermont Ferrand Cedex, Puy-de-Dome, France, 63011
France, Sarthe LE MANS, Sarthe, France, 72000
France, Val-de-Marne Villejuif, Val-de-Marne, France, 94805
Germany, Baden-Wurttemberg Friedrichshafen, Baden-Wurttemberg, Germany, 88045
Germany, Bayern Erlangen, Bayern, Germany, 91054
Germany, Bayern Muenchen, Bayern, Germany, 80337
Germany, Hessen Offenbach, Hessen, Germany, 63069
Germany, Hessen Wiesbaden, Hessen, Germany, 65199
Germany, Niedersachsen Hannover, Niedersachsen, Germany, 30177
Germany, Nordrhein-Westfalen Bonn, Nordrhein-Westfalen, Germany, 53111
Germany, Nordrhein-Westfalen Essen, Nordrhein-Westfalen, Germany, 45136
Germany, Nordrhein-Westfalen Paderborn, Nordrhein-Westfalen, Germany, 60314
Germany, Saarland Saarbruecken, Saarland, Germany, 66113
Germany, Sachsen Dresden, Sachsen, Germany, 01307
Germany, Thuringen Nordhausen, Thuringen, Germany, 99734
Hungary, Bacs-Kiskun Kecskemet, Bacs-Kiskun, Hungary, 6000
Hungary, Baranya Pecs, Baranya, Hungary, 7621
Hungary, Borsod-Abauj-Zemplen Miskolc, Borsod-Abauj-Zemplen, Hungary, 3526
Hungary, Budapest Budapest, Hungary, 1145
Hungary, Budapest Budapest, Hungary, 1122
Hungary, Budapest Budapest, Hungary, 1032
Hungary, Debrecen Debrecen, Hungary, 4032
Hungary, Kaposvar Kaposvar, Hungary, 7400
Ireland, Cork Cork, Ireland, T12 DV56
Ireland, Dublin dublin, Dublin, Ireland, 8
Israel, N/A Afula, N/A, Israel, 1834111
Israel, N/A Ashdod, N/A, Israel, 7747629
Israel, N/A Beer Sheva, N/A, Israel, 8410101
Israel, N/A Haifa, N/A, Israel, 3109601
Israel, N/A Jerusalem, N/A, Israel, 9103102
Israel, N/A Jerusalem, N/A, Israel, 9112001
Israel, N/A Kfar-Saba, N/A, Israel, 4428164
Israel, N/A Nazareth, N/A, Israel, 1641101
Israel, N/A Petah Tikva, N/A, Israel, 4941492
Israel, N/A Ramat Gan, N/A, Israel, 5262000
Israel, N/A Rehovot, N/A, Israel, 7661041
Israel, N/A Tel Aviv, N/A, Israel, 6423906
Israel, N/A Tel Aviv, N/A, Israel, 6789140
Japan, Aichi Nagoya, Aichi, Japan, 464-8681
Japan, Chiba Chiba, Japan, 260-8717
Japan, Chiba kashiwa, Chiba, Japan, 2778577
Japan, Fukushima Fukushima, Japan, 960-1295
Japan, Hiroshima Hiroshima, Japan, 730-8518
Japan, Hokkaido Sapporo, Hokkaido, Japan, 003-0804
Japan, Hyogo Nishinomiya, Hyogo, Japan, 663-8501
Japan, Kanagawa Sagamihara, Kanagawa, Japan, 252-0375
Japan, Kumamoto Kumamoto, Japan, 860-8556
Japan, Osaka Osaka, Japan, 540-0006
Japan, Saitama Hidaka, Saitama, Japan, 350-1298
Japan, Saitama Kitaadachi-gun, Saitama, Japan, 362-0806
Japan, Shizuoka Sunto-gun, Shizuoka, Japan, 411-8777
Japan, Tokyo Tokyo, Japan, 135-8550
Japan, Tokyo Tokyo, Japan, 142-8666
Japan, Tokyo Tokyo, Japan, 105-8470
Korea, Republic of, Kyonggi-do Goyang-si, Kyonggi-do, Korea, Republic of, 10408
Korea, Republic of, Seoul Seoul, Korea, Republic of, 03722
Korea, Republic of, Seoul Seoul, Korea, Republic of, 06351
Korea, Republic of, Seoul Seoul, Korea, Republic of, 03080
Korea, Republic of, Seoul Songpagu, Seoul, Korea, Republic of, 05505
New Zealand, Bay of Plenty Tauranga, Bay of Plenty, New Zealand, 3112
New Zealand, Canterbury Christchurch, Canterbury, New Zealand, 8011
New Zealand, Wellington Wellington, New Zealand, 6021
Poland, Dolnoslaskie Wrocław, Dolnoslaskie, Poland, 53-413
Poland, Kujawsko-pomorskie Bydgoszcz, Kujawsko-pomorskie, Poland, 85-796
Poland, Lodzkie Lodz, Lodzkie, Poland, 93-338
Poland, Mazowieckie Ostroleka, Mazowieckie, Poland, 07-410
Poland, Mazowieckie Warszawa, Mazowieckie, Poland, 02-781
Poland, Mazowieckie Wieliszew, Mazowieckie, Poland, 05-135
Poland, Podlaskie Bialystok, Podlaskie, Poland, 15-027
Poland, Pomorskie Gdansk, Pomorskie, Poland, 80-219
Poland, Pomorskie Gdynia, Pomorskie, Poland, 81-519
Poland, Slaskie Bielsko-Biala, Slaskie, Poland, 43-300
Poland, Slaskie Bytom, Slaskie, Poland, 41-900
Poland, Slaskie Gliwice, Slaskie, Poland, 44-101
Portugal, Aveiro Lisboa, Aveiro, Portugal, 1649-035
Portugal, Lisboa Lisboa, Portugal, 1649-035
Portugal, Porto Porto, Portugal, 4200-072
Portugal, Porto Porto, Portugal, 4099-001
Russian Federation, Arkhangel skaya oblast Arkhangelsk, Arkhangel skaya oblast, Russian Federation, 163045
Russian Federation, Baskortostan, Respublika Ufa, Baskortostan, Respublika, Russian Federation, 450054
Russian Federation, Moskva Moscow, Moskva, Russian Federation, 121359
Russian Federation, Moskva Moscow, Moskva, Russian Federation, 115478
Russian Federation, Moskva Moscow, Moskva, Russian Federation, 125367
Russian Federation, Ryazanskaya oblast Ryazan, Ryazanskaya oblast, Russian Federation, 390013
Russian Federation, Sankt-Peterburg Saint Petersburg, Sankt-Peterburg, Russian Federation, 195271
Russian Federation, Sankt-Peterburg Saint Petersburg, Sankt-Peterburg, Russian Federation, 197758
Russian Federation, Tatarstan, Respublika Kazan, Tatarstan, Respublika, Russian Federation, 420029
Russian Federation, Tomskaya oblast Tomsk, Tomskaya oblast, Russian Federation, 634028
Spain, Barcelona Barcelona, Spain, 08036
Spain, Barcelona Barcelona, Spain, 08035
Spain, Barcelona Barcelona, Spain, 08023
Spain, Barcelona Hospitalet de Llobregat, Barcelona, Spain, 08908
Spain, Jaen Jaen, Spain, 23007
Spain, La Coruna A Coruna, La Coruna, Spain, 15006
Spain, Madrid Madrid, Spain, 28040
Spain, Madrid Madrid, Spain, 28041
Spain, Madrid Madrid, Spain, 28034
Spain, Madrid Pozuelo de Alarcon, Madrid, Spain, 28223
Spain, Madrid, Comunidad de Madrid, Madrid, Comunidad de, Spain, 28007
Spain, Sevilla Sevilla, Spain, 41013
Spain, Valencia Valencia, Spain, 46015
Spain, Valenciana, Comunitat Valencia, Valenciana, Comunitat, Spain, 46011
Taiwan, Taichung Taichung, Taiwan, 40447
Taiwan, Tainan Tainan, Taiwan, 704
Taiwan, Taipei Taipei, Taiwan, 11259
Taiwan, Taipei Taipei, Taiwan, 10048
Taiwan, Taoyuan Taoyuan, Taiwan, 333
Ukraine, Dnipropetrovska oblast Dnipro, Dnipropetrovska oblast, Ukraine, 49102
Ukraine, Dnipropetrovska oblast Kryviy Rih, Dnipropetrovska oblast, Ukraine, 50048
Ukraine, Ivano-Frankivska oblast Ivano-Frankivsk, Ivano-Frankivska oblast, Ukraine, 76018
Ukraine, Kharkivska oblast Kharkiv, Kharkivska oblast, Ukraine, 61070
Ukraine, Khersonska oblast Antonivka village, Khersonska oblast, Ukraine, 73000
Ukraine, Khmelnytska oblast Khmelnitskiy, Khmelnytska oblast, Ukraine, 29000
Ukraine, Kyiv Kyiv, Ukraine, 03115
Ukraine, Kyivska oblast Kyiv, Kyivska oblast, Ukraine, 03022
Ukraine, Odeska oblast Odesa, Odeska oblast, Ukraine, 65025
Ukraine, Odeska oblast Odesa, Odeska oblast, Ukraine, 65055
Ukraine, Zaporizka oblast Zaporizhzhia, Zaporizka oblast, Ukraine, 69035
United Kingdom, Bristol, City of Bristol, Bristol, City of, United Kingdom, BS2 8ED
United Kingdom, England Nottingham, England, United Kingdom, ng5 1pb
United Kingdom, Essex Colchester, Essex, United Kingdom, CO4 5JL
United Kingdom, London, City of London, London, City of, United Kingdom, SE1 9RY
United Kingdom, London, City of London, London, City of, United Kingdom, SW17 0QT
United Kingdom, London, City of London, London, City of, United Kingdom, EC1A 7BE
United Kingdom, United Kingdom Solihull, United Kingdom, United Kingdom, B91 2JL
United Kingdom, United Kingdom Truro, United Kingdom, United Kingdom, TR1 3LJ
United States, AL Daphne, AL, United States, 36526
United States, AZ Goodyear, AZ, United States, 85338
United States, AZ Tucson, AZ, United States, 85704
United States, CA Los Angeles, CA, United States, 90048
United States, CA Mountain View, CA, United States, 94040
United States, CA Palo Alto, CA, United States, 94304
United States, CA Sacramento, CA, United States, 95817
United States, CO Aurora, CO, United States, 80045
United States, FL Jacksonville, FL, United States, 32207
United States, GA Newnan, GA, United States, 30265
United States, IA Waterloo, IA, United States, 50702
United States, IL Chicago, IL, United States, 60637
United States, IL Skokie, IL, United States, 60077
United States, IL Zion, IL, United States, 60099
United States, IN Goshen, IN, United States, 46526
United States, KY Louisville, KY, United States, 40202
United States, MA Boston, MA, United States, 02114
United States, MA Danvers, MA, United States, 01923
United States, MA Newton, MA, United States, 02462
United States, MD Bethesda, MD, United States, 20817
United States, MI Detroit, MI, United States, 48202
United States, MN Rochester, MN, United States, 55905
United States, MT Billings, MT, United States, 59102
United States, NE Omaha, NE, United States, 68130
United States, NJ Teaneck, NJ, United States, 07666
United States, NY New York, NY, United States, 10065
United States, OK Tulsa, OK, United States, 74133
United States, OR Portland, OR, United States, 97239
United States, OR Tigard, OR, United States, 97223
United States, PA Danville, PA, United States, 17822
United States, PA Philadelphia, PA, United States, 19124
United States, PA Philadelphia, PA, United States, 19111
United States, PR San Juan, PR, United States, 00935
United States, SC Charleston, SC, United States, 29425
United States, TN Nashville, TN, United States, 37203
United States, TX Austin, TX, United States, 78731
United States, TX Dallas, TX, United States, 75231
United States, TX Dallas, TX, United States, 75246
United States, TX Houston, TX, United States, 77030-4009
United States, TX Houston, TX, United States, 77024
United States, TX Plano, TX, United States, 75075
United States, TX Tyler, TX, United States, 75702
United States, VA Midlothian, VA, United States, 23114
United States, VA Norfolk, VA, United States, 23502
United States, WA Kennewick, WA, United States, 99336
United States, WA Spokane, WA, United States, 99208