Safety and Efficacy of Lenvatinib (E7080/MK-7902) with Pembrolizumab (MK-3475) in Combination with Transarterial Chemoembolization (TACE) in Participants with Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Trial Identifier: 7902-012
Sponsor: MSD
Collaborator:
Eisai Inc.
Start Date: May 2020
Primary Completion Date: June 2028
Study Completion Date: December 2029
Condition: Cancer - Other

Available Languages

For questions about your Trial Results Summary, please see Sponsor contact section within your Trial Results Summary.

Language Description
Protocol Plain Language Summary – English

Trial Locations

Country Location
Australia, New South Wales Kogarah, New South Wales, Australia, 2217
Australia, New South Wales Westmead, New South Wales, Australia, 2145
Australia, Queensland Brisbane, Queensland, Australia, 4102
Australia, Victoria Heidelberg, Victoria, Australia, 3084
Australia, Victoria Melbourne, Victoria, Australia, 3004
Australia, Western Australia Perth, Western Australia, Australia, 6000
Brazil, Rio Grande do Norte Natal, Rio Grande do Norte, Brazil, 59075-740
Brazil, Rio Grande do Sul PORTO ALEGRE, Rio Grande do Sul, Brazil, 91350-200
Brazil, Santa Catarina Blumenau, Santa Catarina, Brazil, 89010-340
Brazil, Sao Paulo Barretos, Sao Paulo, Brazil, 14784400
Brazil, Sao Paulo jau, Sao Paulo, Brazil, 17210-120
Brazil, Sao Paulo Sao Jose do Rio Preto, Sao Paulo, Brazil, 15090-000
Brazil, Sao Paulo Sao Paulo, Brazil, 01509-900
Brazil, Sao Paulo São Paulo, Sao Paulo, Brazil, 01323-001
Chile, Araucania Temuco, Araucania, Chile, 4800827
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 8330024
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 8420383
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 7560908
China, Anhui Heifei, Anhui, China, 230001
China, Beijing Beijing, China, 100730
China, Beijing Beijing, China, 100142
China, Chongqing Chongqing, China, 400042
China, Chongqing Wanzhou, Chongqing, China, 404199
China, Fujian Fuzhou, Fujian, China, 350014
China, Fujian Fuzhou, Fujian, China, 350001
China, Fujian Xiamen, Fujian, China, 361015
China, Guangdong Guangzhou, Guangdong, China, 510515
China, Guangdong Guangzhou, Guangdong, China, 510080
China, Guangdong Guangzhou, Guangdong, China, 510000
China, Guangdong Guangzhou, Guangdong, China, 510700
China, Guangdong zhuhai, Guangdong, China, 519000
China, Guangxi Nanning, Guangxi, China, 530021
China, Hainan Haikou, Hainan, China, 570311
China, Heilongjiang Harbin, Heilongjiang, China, 150081
China, Henan Zhengzhou, Henan, China, 450008
China, Hubei Wuhan, Hubei, China, 430079
China, Hubei Wuhan, Hubei, China, 430030
China, Hunan Changsha, Hunan, China, 410005
China, Hunan Changsha, Hunan, China, 430079
China, Jiangsu Suzhou, Jiangsu, China, 215006
China, Jiangxi Nanchang, Jiangxi, China, 330029
China, Shaanxi Xi'an, Shaanxi, China, 710126
China, Shanghai Shanghai, China, 200032
China, Shanghai Shanghai, China, 200028
China, Shanxi Xi an, Shanxi, China, 710048
China, Sichuan Chengdu, Sichuan, China, 610041
China, Sichuan Suining, Sichuan, China, 629000
China, Tianjin Tianjin, China, 300060
China, Tianjin Tianjin, China, 300170
China, Yunnan Kunming, Yunnan, China, 650200
China, Zhejiang Hangzhou, Zhejiang, China, 310018
China, Zhejiang Hangzhou, Zhejiang, China, 310022
China, Zhejiang Hangzhou, Zhejiang, China, 310009
China, Zhejiang Ningbo, Zhejiang, China, 315041
Colombia, Antioquia Medellin, Antioquia, Colombia, 050034
Colombia, Distrito Capital de Bogota Bogota, Distrito Capital de Bogota, Colombia, 110221
Colombia, Santander Piedecuesta, Santander, Colombia, 681017
Colombia, Valle del Cauca Cali, Valle del Cauca, Colombia, 760032
Denmark, Hovedstaden Herlev, Hovedstaden, Denmark, 2730
Denmark, Midtjylland Aarhus N, Midtjylland, Denmark, 8200
Denmark, Syddanmark Odense, Syddanmark, Denmark, 5000
France, Auvergne Lyon, Auvergne, France, 69004
France, Bouches-du-Rhone Marseille, Bouches-du-Rhone, France, 13005
France, Gironde Pessac Cedex, Gironde, France, 33604
France, Meurthe-et-Moselle Vandoeuvre les Nancy, Meurthe-et-Moselle, France, 54500
France, Val-de-Marne Creteil, Val-de-Marne, France, 94000
France, Val-de-Marne Villejuif, Val-de-Marne, France, 94800
Germany, Baden-Wurttemberg Freiburg, Baden-Wurttemberg, Germany, 79106
Germany, Berlin Berlin, Germany, 13353
Germany, Hamburg Hamburg, Germany, 20246
Germany, Hessen Frankfurt am Main, Hessen, Germany, 60488
Germany, Niedersachsen Hannover, Niedersachsen, Germany, 30625
Germany, Nordrhein-Westfalen Bonn, Nordrhein-Westfalen, Germany, 53127
Germany, Sachsen Leipzig, Sachsen, Germany, 04103
Germany, Sachsen-Anhalt Halle (Saale), Sachsen-Anhalt, Germany, 06120
Germany, Schleswig-Holstein Luebeck, Schleswig-Holstein, Germany, 23538
Hong Kong, N/A Shatin, N/A, Hong Kong, 000
Hungary, Budapest Budapest, Hungary, 1085
Hungary, Somogy Kaposvár, Somogy, Hungary, 7400
Hungary, Zala Zalaegerszeg, Zala, Hungary, 8900
Ireland, Dublin Dublin, Ireland, D04 YN63
Israel, N/A Afula, N/A, Israel, 18341
Israel, N/A Haifa, N/A, Israel, 3109601
Israel, N/A Jerusaelm, N/A, Israel, 9112001
Israel, N/A Petah Tikva, N/A, Israel, 4941492
Israel, N/A Tel Aviv, N/A, Israel, 6423906
Italy, Brescia BRESCIA, Brescia, Italy, 25123
Italy, Campania Napoli, Campania, Italy, 80147
Italy, Milano Milan, Milano, Italy, 20162
Italy, Milano Milano, Italy, 20122
Italy, Napoli Napoli, Italy, 80131
Italy, Piemonte Torino, Piemonte, Italy, 10128
Italy, Ravenna Ravenna, Italy, 48121
Italy, Roma Roma, Italy, 00168
Italy, Sicilia Messina, Sicilia, Italy, 98124
Japan, Chiba Chiba, Japan, 260-8677
Japan, Chiba kashiwa, Chiba, Japan, 2778577
Japan, Ehime Toon, Ehime, Japan, 791-0295
Japan, Fukuoka Fukuoka, Japan, 810-8563
Japan, Fukuoka Kurume, Fukuoka, Japan, 830-0011
Japan, Hiroshima Hiroshima, Japan, 7348551
Japan, Hokkaido Sapporo, Hokkaido, Japan, 060-0033
Japan, Ishikawa Kanazawa, Ishikawa, Japan, 920-8641
Japan, Kagawa Takamatsu, Kagawa, Japan, 760-8557
Japan, Kanagawa Kawasaki, Kanagawa, Japan, 213-8587
Japan, Kanagawa Yokohama, Kanagawa, Japan, 241-8515
Japan, Kanagawa Yokohama, Kanagawa, Japan, 232-0024
Japan, Kumamoto Kumamoto, Japan, 860-8556
Japan, Kyoto Kyoto, Japan, 602-8566
Japan, Nara Kashihara, Nara, Japan, 634-8522
Japan, Osaka Osaka, Japan, 543-8555
Japan, Osaka Osaka, Japan, 541-8567
Japan, Osaka Osakasayama, Osaka, Japan, 5898511
Japan, Saga Saga, Japan, 840-8571
Japan, Saitama Iruma-gun, Saitama, Japan, 350-0495
Japan, Shizuoka Sunto-gun, Shizuoka, Japan, 411-8777
Japan, Tochigi Shimotsuke, Tochigi, Japan, 329-0498
Japan, Tokyo Tokyo, Japan, 105-8470
Japan, Tokyo Tokyo, Japan, 113-8655
Japan, Tokyo Tokyo, Japan, 113-0033
Korea, Republic of, Jeonranamdo Hwasun, Jeonranamdo, Korea, Republic of, 58128
Korea, Republic of, Kyonggi-do Seongnam-si, Kyonggi-do, Korea, Republic of, 13620
Korea, Republic of, Pusan-Kwangyokshi Busan, Pusan-Kwangyokshi, Korea, Republic of, 49241
Korea, Republic of, Seoul Seoul, Korea, Republic of, 03722
Korea, Republic of, Seoul Seoul, Korea, Republic of, 05505
Korea, Republic of, Seoul Seoul, Korea, Republic of, 06351
Korea, Republic of, Seoul Seoul, Korea, Republic of, 03080
Korea, Republic of, Seoul Seoul, Korea, Republic of, 06591
Korea, Republic of, Seoul Seoul, Korea, Republic of, 08308
Korea, Republic of, Taegu-Kwangyokshi Daegu, Taegu-Kwangyokshi, Korea, Republic of, 41944
Netherlands, Limburg Maastricht, Limburg, Netherlands, 6202AZ
Netherlands, Noord-Holland Amsterdam, Noord-Holland, Netherlands, 1105 AZ
Netherlands, Utrecht Utrecht, Netherlands, 3584 CX
Netherlands, Zuid-Holland Leiden, Zuid-Holland, Netherlands, 2333 ZA
Netherlands, Zuid-Holland Rotterdam, Zuid-Holland, Netherlands, 3015 GD
New Zealand, Auckland Auckland, New Zealand, 1023
Norway, Oslo Oslo, Norway, 0450
Portugal, Coimbra Coimbra, Portugal, 3000-075
Portugal, Lisboa Lisboa, Portugal, 1169-050
Portugal, Porto Porto, Portugal, 4099-001
Portugal, Porto Porto, Portugal, 4200-072
Portugal, Porto Porto, Portugal, 4200-319
Spain, Madrid Madrid, Spain, 28040
Spain, Madrid Madrid, Spain, 28007
Spain, Madrid Madrid, Spain, 28034
Spain, Madrid Majadahonda, Madrid, Spain, 28222
Spain, Sevilla Sevilla, Spain, 41013
Spain, Valenciana, Comunitat Valencia, Valenciana, Comunitat, Spain, 46014
Taiwan, Kaohsiung Kaohsiung, Taiwan, 807
Taiwan, Kaohsiung Kaohsiung City, Kaohsiung, Taiwan, 833
Taiwan, Taichung Taichung, Taiwan, 40447
Taiwan, Taichung Taichung, Taiwan, 407
Taiwan, Tainan Tainan, Taiwan, 70457
Taiwan, Taipei Taipei, Taiwan, 112201
Taiwan, Taipei Taipei, Taiwan, 10002
Taiwan, Taoyuan Taoyuan, Taiwan, 333
Thailand, Krung Thep Maha Nakhon Bangkok, Krung Thep Maha Nakhon, Thailand, 10700
Thailand, Krung Thep Maha Nakhon Bangkok, Krung Thep Maha Nakhon, Thailand, 10330
Thailand, Krung Thep Maha Nakhon Bangkok, Krung Thep Maha Nakhon, Thailand, 10400
Turkey, Ankara Ankara, Turkey, 06800
Turkey, Ankara Ankara, Turkey, 06230
Turkey, Edirne Edirne, Turkey, 22030
Turkey, Istanbul Istanbul, Turkey, 34093
Turkey, Izmir Izmir, Turkey, 35100
Turkey, Izmir Izmir, Turkey, 35575
Turkey, Konya Konya, Turkey, 42080
Turkey, Malatya Malatya, Turkey, 44280
Ukraine, Kharkivska oblast Kharkiv, Kharkivska oblast, Ukraine, 61070
Ukraine, Kharkivska oblast Kharkiv, Kharkivska oblast, Ukraine, 61024
Ukraine, Kyivska oblast Kyiv, Kyivska oblast, Ukraine, 03126
United Kingdom, London, City of London, London, City of, United Kingdom, SW3 6JJ
United Kingdom, London, City of London, London, City of, United Kingdom, EC1A 7BE
United Kingdom, London, City of Sutton, London, City of, United Kingdom, SM25PT
United States, AZ Tucson, AZ, United States, 85711
United States, CA La Jolla, CA, United States, 92037
United States, CA Los Angeles, CA, United States, 90033
United States, CA Los Angeles, CA, United States, 90404
United States, CA Orange, CA, United States, 92868
United States, CT New Haven, CT, United States, 06520
United States, FL Tampa, FL, United States, 33606
United States, IA Iowa City, IA, United States, 52242
United States, ID Boise, ID, United States, 83712
United States, KS Westwood, KS, United States, 66205
United States, KY Louisville, KY, United States, 40202
United States, LA New Orleans, LA, United States, 70112
United States, MI Detroit, MI, United States, 48202
United States, MO St. Louis, MO, United States, 63110
United States, NC Winston-Salem, NC, United States, 27157
United States, NM Albuquerque, NM, United States, 87106
United States, NY Lake Success, NY, United States, 11042
United States, NY New York, NY, United States, 10029
United States, OH Cincinnati, OH, United States, 45219
United States, OH Columbus, OH, United States, 43210
United States, OH Sylvania, OH, United States, 43560
United States, OK Oklahoma City, OK, United States, 73104
United States, OR Portland, OR, United States, 97239
United States, PA Hershey, PA, United States, 17033-0850
United States, PR Ponce, PR, United States, 00717
United States, PR San Juan, PR, United States, 00921-3201
United States, PR San Juan, PR, United States, 00927
United States, PR San Juan, PR, United States, 00918
United States, TX Houston, TX, United States, 77030
United States, WV Huntington, WV, United States, 25701