Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)

Trial Identifier: 3475-991
Sponsor: MSD
Start Date: February 2020
Primary Completion Date: October 2022
Study Completion Date: December 2025

Available Languages

For questions about your Trial Results Summary, please see Sponsor contact section within your Trial Results Summary.

Language Description
Protocol Plain Language Summary - English

Trial Locations

Country Location
Australia, New South Wales Camperdown, New South Wales, Australia, 2050
Australia, New South Wales Port Macquarie, New South Wales, Australia, 2444
Australia, New South Wales Wagga Wagga, New South Wales, Australia, 2650
Australia, Queensland Greenslopes, Queensland, Australia, 4120
Australia, Queensland Tugun, Queensland, Australia, 4224
Australia, Victoria Box Hill, Victoria, Australia, 3128
Australia, Victoria Clayton, Victoria, Australia, 3168
Australia, Victoria Melbourne, Victoria, Australia, 3000
Australia, Western Australia Murdoch, Western Australia, Australia, 6150
Austria, Oberosterreich Linz, Oberosterreich, Austria, 4020
Austria, Salzburg Salzburg, Austria, 5020
Austria, Wien Wien, Austria, 1020
Austria, Wien Wien, Austria, 1090
Brazil, Ceara Fortaleza, Ceara, Brazil, 60135-237
Brazil, Parana Curitiba, Parana, Brazil, 80510-130
Brazil, Rio Grande do Sul Passo Fundo, Rio Grande do Sul, Brazil, 99010-080
Brazil, Rio Grande do Sul Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
Brazil, Santa Catarina Blumenau, Santa Catarina, Brazil, 89010-340
Brazil, Sao Paulo Jau, Sao Paulo, Brazil, 17210-120
Brazil, Sao Paulo Sao Paulo, Brazil, 01246-000
Canada, ON Ottawa, ON, Canada, K1H 8L6
Canada, ON St. Catharines, ON, Canada, L2S 0A9
Canada, QC Greenfield Park, QC, Canada, J4V 2H1
Canada, QC Montreal, QC, Canada, H2X 3E4
Canada, QC Montreal, QC, Canada, H3T 1M5
Canada, QC Quebec, QC, Canada, G1R 2J6
Chile, Araucania Temuco, Araucania, Chile, 4780000
Chile, Coquimbo La Serena, Coquimbo, Chile, 1720430
Chile, Maule Talca, Maule, Chile, 3465584
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 8420383
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 7650568
Chile, Region M. de Santiago Santiago, Region M. de Santiago, Chile, 8330032
Chile, Valparaiso Vina del Mar, Valparaiso, Chile, 2520598
China, Beijing Beijing, China, 100034
China, Zhejiang Hangzhou, Zhejiang, China, 310014
China, Zhejiang Wenzhou, Zhejiang, China, 325000
Colombia, Atlantico Barranquilla, Atlantico, Colombia, 080020
Colombia, Cesar Valledupar, Cesar, Colombia, 200001
Colombia, Distrito Capital de Bogota Bogota, Distrito Capital de Bogota, Colombia, 110221
Colombia, Distrito Capital de Bogota Bogota, Distrito Capital de Bogota, Colombia, 110321
Colombia, Valle del Cauca Cali, Valle del Cauca, Colombia, 760042
Denmark, Hovedstaden Copenhagen, Hovedstaden, Denmark, 2100
Denmark, Hovedstaden Herlev, Hovedstaden, Denmark, 2730
Denmark, Nordjylland Aalborg, Nordjylland, Denmark, 9000
Denmark, Syddanmark Odense, Syddanmark, Denmark, 5000
Denmark, Syddanmark Vejle, Syddanmark, Denmark, 7100
Finland, Mellersta Finland Jyvaskyla, Mellersta Finland, Finland, 40620
Finland, Pirkanmaa Tampere, Pirkanmaa, Finland, 33520
Finland, Varsinais-Suomi Helsinki, Varsinais-Suomi, Finland, 00290
Finland, Varsinais-Suomi Turku, Varsinais-Suomi, Finland, 20521
France, Auvergne Lyon, Auvergne, France, 69373
France, Bas-Rhin Strasbourg, Bas-Rhin, France, 67200
France, Bretagne Brest, Bretagne, France, 29200
France, Cote-d Or Dijon, Cote-d Or, France, 21079
France, Doubs Besancon, Doubs, France, 25000
France, Gironde Bordeaux, Gironde, France, 33076
France, Hauts-de-Seine Suresnes, Hauts-de-Seine, France, 92151
France, Ille-et-Vilaine Rennes, Ille-et-Vilaine, France, 35033
France, Marne Reims, Marne, France, 51726
France, Meurthe-et-Moselle Nancy, Meurthe-et-Moselle, France, 54100
France, Nord-Pas-de-Calais Lille, Nord-Pas-de-Calais, France, 59000
France, Rhone Pierre Benite, Rhone, France, 69310
France, Val-de-Marne Creteil, Val-de-Marne, France, 94010
Germany, Baden-Wurttemberg Freiburg, Baden-Wurttemberg, Germany, 79106
Germany, Bayern Muenchen, Bayern, Germany, 81377
Germany, Bayern Munchen, Bayern, Germany, 81675
Germany, Bayern Nurnberg, Bayern, Germany, 90419
Germany, Berlin Berlin, Germany, 10117
Germany, Hamburg Hamburg, Germany, 20246
Germany, Niedersachsen Braunschweig, Niedersachsen, Germany, 38126
Germany, Sachsen Dresden, Sachsen, Germany, 01307
Germany, Sachsen-Anhalt Magdeburg, Sachsen-Anhalt, Germany, 39120
Ireland, Cork Cork, Ireland, T12 DC4A
Ireland, Dublin Dublin, Ireland, D24 NR0A
Ireland, Dublin Dublin, Ireland, DO4 YN63
Ireland, Dublin Dublin, Ireland, 00009
Ireland, Limerick Limerick, Ireland, V94 F858
Ireland, Waterford Waterford, Ireland, X91 ER8E
Israel, N/A Haifa, N/A, Israel, 3109601
Israel, N/A Jerusalem, N/A, Israel, 9112001
Israel, N/A Kfar Saba, N/A, Israel, 4428164
Israel, N/A Petach Tikva, N/A, Israel, 4941492
Israel, N/A Tel Aviv, N/A, Israel, 6423906
Israel, N/A Zerifin, N/A, Israel, 70300
Italy, Bari Bari, Italy, 70124
Italy, Catania Catania, Italy, 95126
Italy, Emilia-Romagna Meldola, Emilia-Romagna, Italy, 47014
Italy, Lombardia Rozzano, Lombardia, Italy, 20089
Italy, Milano Milano, Italy, 20133
Italy, Napoli Napoli, Italy, 80131
Italy, Pordenone Aviano, Pordenone, Italy, 33081
Italy, Roma Roma, Italy, 00168
Italy, Terni Terni, Italy, 05100
Italy, Verona Verona, Italy, 37126
Japan, Chiba Chiba, Japan, 260-8717
Japan, Chiba Sakura, Chiba, Japan, 285-8741
Japan, Ehime Toon, Ehime, Japan, 791-0295
Japan, Fukuoka Fukuoka, Japan, 812-0033
Japan, Hokkaido Sapporo, Hokkaido, Japan, 060-8543
Japan, Kanagawa Sagamihara, Kanagawa, Japan, 252-0375
Japan, Kanagawa Yokohama, Kanagawa, Japan, 232-0024
Japan, Nagano Nagano, Japan, 381-8551
Japan, Nara Kashihara, Nara, Japan, 634-8522
Japan, Osaka Osaka, Japan, 545-8586
Japan, Osaka Osakasayama, Osaka, Japan, 589-8511
Japan, Osaka Suita, Osaka, Japan, 565-0871
Japan, Saitama Hidaka, Saitama, Japan, 350-1298
Japan, Saitama Koshigaya, Saitama, Japan, 343-8555
Japan, Shizuoka Hamamatsu, Shizuoka, Japan, 431-3192
Japan, Tokyo Tokyo, Japan, 113-8603
Japan, Tokyo Tokyo, Japan, 162-8666
Japan, Tokyo Tokyo, Japan, 105-8470
Japan, Yamaguchi Ube, Yamaguchi, Japan, 755-8505
Korea, Republic of, Jeonranamdo Jeollanam-do, Jeonranamdo, Korea, Republic of, 58128
Korea, Republic of, Kyonggi-do Gyeonggi-do, Kyonggi-do, Korea, Republic of, 10408
Korea, Republic of, Kyonggi-do Seongnam-si, Kyonggi-do, Korea, Republic of, 13620
Korea, Republic of, Seoul Seoul, Korea, Republic of, 05505
Korea, Republic of, Seoul Seoul, Korea, Republic of, 03080
Korea, Republic of, Seoul Seoul, Korea, Republic of, 03722
Korea, Republic of, Taegu-Kwangyokshi Daegu, Taegu-Kwangyokshi, Korea, Republic of, 41404
Mexico, Chiapas Tuxtla Gutierrez, Chiapas, Mexico, 29090
Mexico, Chihuahua Chihuahua, Mexico, 31000
Mexico, Jalisco Guadalajara, Jalisco, Mexico, 44280
Mexico, Mexico Mexico City, Mexico, Mexico, 03310
Mexico, Mexico Mexico City, Mexico, Mexico, 04700
Mexico, Queretaro Queretaro, Mexico, 76070
Netherlands, Gelderland Nijmegen, Gelderland, Netherlands, 6500 HB
Netherlands, Noord-Holland Amsterdam, Noord-Holland, Netherlands, 1081 HV
Netherlands, Noord-Holland Amsterdam, Noord-Holland, Netherlands, 1066 CX
Netherlands, Overijssel Zwolle, Overijssel, Netherlands, 8025 AB
Netherlands, Utrecht Amersfoort, Utrecht, Netherlands, 3813 TZ
Netherlands, Utrecht Utrecht, Netherlands, 3543 AZ
Netherlands, Zuid-Holland Schiedam, Zuid-Holland, Netherlands, 3118 JH
New Zealand, Auckland Auckland, New Zealand, 1023
Peru, Ariqipa Arequipa, Ariqipa, Peru, 04001
Peru, La Libertad Trujillo, La Libertad, Peru, 13011
Peru, Lima Lima, Peru, 15076
Peru, Lima Lima, Peru, 15033
Peru, Lima Lima, Peru, 15036
Poland, Kujawsko-pomorskie Bydgoszcz, Kujawsko-pomorskie, Poland, 85-796
Poland, Kujawsko-pomorskie Bydgoszcz, Kujawsko-pomorskie, Poland, 85-094
Poland, Kujawsko-pomorskie Torun, Kujawsko-pomorskie, Poland, 87-100
Poland, Malopolskie Krakow, Malopolskie, Poland, 30-688
Poland, Mazowieckie Radom, Mazowieckie, Poland, 26-600
Poland, Podkarpackie Przemysl, Podkarpackie, Poland, 37-700
Poland, Slaskie Bytom, Slaskie, Poland, 41-902
Poland, Wielkopolskie Poznan, Wielkopolskie, Poland, 61-848
Poland, Zachodniopomorskie Koszalin, Zachodniopomorskie, Poland, 75-581
Poland, Zachodniopomorskie Szczecin, Zachodniopomorskie, Poland, 71-434
Russian Federation, Krasnoyarskiy kray Krasnoyarsk, Krasnoyarskiy kray, Russian Federation, 660133
Russian Federation, Moskva Moscow, Moskva, Russian Federation, 105077
Russian Federation, Moskva Moscow, Moskva, Russian Federation, 117997
Russian Federation, Nizhegorodskaya oblast Nizhny Novgorod, Nizhegorodskaya oblast, Russian Federation, 603074
Russian Federation, Omskaya oblast Omsk, Omskaya oblast, Russian Federation, 644013
Spain, Barcelona Hospitalet de Llobregat, Barcelona, Spain, 08908
Spain, Gerona Girona, Gerona, Spain, 17007
Spain, Lugo Lugo, Spain, 27003
Spain, Madrid Madrid, Spain, 28041
Spain, Madrid Madrid, Spain, 28034
Spain, Madrid Madrid, Spain, 28040
Spain, Sevilla Sevilla, Spain, 41071
Switzerland, Grisons Chur, Grisons, Switzerland, 7000
Switzerland, Sankt Gallen St. Gallen, Sankt Gallen, Switzerland, 9007
Switzerland, Vaud Lausanne, Vaud, Switzerland, 1011
Switzerland, Zurich Zuerich, Zurich, Switzerland, 8091
Taiwan, Kaohsiung Kaohsiung, Taiwan, 83301
Taiwan, Tainan Tainan, Taiwan, 70457
Taiwan, Taipei Taipei, Taiwan, 11217
Taiwan, Taipei Taipei, Taiwan, 100
Taiwan, Taoyuan Taoyuan, Taiwan, 333
Thailand, Khon Kaen Khon Kaen, Thailand, 40002
Thailand, Krung Thep Maha Nakhon Bangkok, Krung Thep Maha Nakhon, Thailand, 10700
Thailand, Krung Thep Maha Nakhon Bangkok, Krung Thep Maha Nakhon, Thailand, 10400
Thailand, Krung Thep Maha Nakhon Bangkok, Krung Thep Maha Nakhon, Thailand, 10330
Turkey, Adana Adana, Turkey, 01130
Turkey, Ankara Ankara, Turkey, 06230
Turkey, Ankara Ankara, Turkey, 06100
Turkey, Ankara Ankara, Turkey, 06800
Turkey, Istanbul Istanbul, Turkey, 34098
Turkey, Izmir Izmir, Turkey, 35100
Turkey, Konya Konya, Turkey, 42080
United Kingdom, Aberdeen City Aberdeen, Aberdeen City, United Kingdom, AB25 2ZN
United Kingdom, Cardiff Cardiff, United Kingdom, CF14 2TL
United Kingdom, Cornwall Truro, Cornwall, United Kingdom, TR1 3LJ
United Kingdom, London, City of London, London, City of, United Kingdom, NW1 2BU
United Kingdom, London, City of London, London, City of, United Kingdom, SW3 6JJ
United States, AK Anchorage, AK, United States, 99503
United States, AK Anchorage, AK, United States, 99508
United States, CA Duarte, CA, United States, 91010
United States, CA Los Angeles, CA, United States, 90404
United States, CO Aurora, CO, United States, 80045
United States, CT Manchester, CT, United States, 06042
United States, CT New Haven, CT, United States, 06510
United States, DC Washington, DC, United States, 20016
United States, GA Atlanta, GA, United States, 30322-1013
United States, IL Chicago, IL, United States, 60637
United States, IL Springfield, IL, United States, 62702
United States, KS Topeka, KS, United States, 66606
United States, MD Baltimore, MD, United States, 21287
United States, MT Billings, MT, United States, 59102
United States, NC Durham, NC, United States, 27710
United States, NV Las Vegas, NV, United States, 89169
United States, NY New York, NY, United States, 10016
United States, NY New York, NY, United States, 10065
United States, NY Syracuse, NY, United States, 13210
United States, OH Cincinnati, OH, United States, 45212
United States, PA Bala Cynwyd, PA, United States, 19004
United States, SC Charleston, SC, United States, 29401
United States, SC Myrtle Beach, SC, United States, 29572
United States, TN Nashville, TN, United States, 37209
United States, VA Fairfax, VA, United States, 22031
United States, VA Virginia Beach, VA, United States, 23462
United States, WA Seattle, WA, United States, 98109