A Study of the Efficacy and Safety of MK-5475 in Participants with Pulmonary Arterial Hypertension (INSIGNIA-PAH: Phase 2/3 Study of an Inhaled sGC Stimulator in PAH) (MK-5475-007)

Trial Identifier:	5475-007
Sponsor:	MSD
Start Date:	May 2021
Primary Completion Date:	January 2024
Study Completion Date:	July 2024
Condition:	Pulmonary Hypertension

Available Languages

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Language	Description
	Protocol Plain Language Summary – English
	Protocol Plain Language Summary – English

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Trial Locations

Country	Location
Argentina, Buenos Aires	Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1425BNG
Argentina, Buenos Aires	Florencio Varela, Buenos Aires, Argentina, 1888
Argentina, Buenos Aires	La Plata, Buenos Aires, Argentina, B1904AAW
Argentina, Buenos Aires	Pilar, Buenos Aires, Argentina, B1629ODT
Argentina, Buenos Aires	Quilmes, Buenos Aires, Argentina, B1878GEG
Argentina, CABA	Buenos Aires, CABA, Argentina, 1039
Argentina, Cordoba	Cordoba, Argentina, X5016KEH
Argentina, Santa Fe	Rosario, Santa Fe, Argentina, S2000DSR
Australia, New South Wales	Kingswood, New South Wales, Australia, 2747
Australia, New South Wales	Macquarie University, New South Wales, Australia, 2109
Australia, New South Wales	Newcastle, New South Wales, Australia, 2305
Belgium, Bruxelles-Capitale, Region de	Brussels, Bruxelles-Capitale, Region de, Belgium, 1070
Belgium, Vlaams-Brabant	Leuven, Vlaams-Brabant, Belgium, 3000
Canada, AB	Calgary, AB, Canada, T1Y 6J4
Canada, ON	Toronto, ON, Canada, M5G 2N2
Canada, QC	Quebec, QC, Canada, G1V 4G5
Colombia, Antioquia	Medellín, Antioquia, Colombia, 050034
Colombia, Distrito Capital de Bogota	Bogota, Distrito Capital de Bogota, Colombia, 110231
Colombia, Santander	Piedecuesta, Santander, Colombia, 681017
France, Finistere	Brest, Finistere, France, 29609
France, Haute-Garonne	Toulouse, Haute-Garonne, France, 31059
France, Nord-Pas-de-Calais	Lille Cedex, Nord-Pas-de-Calais, France, 59037
France, Seine-Maritime	Rouen, Seine-Maritime, France, 76031
France, Val-de-Marne	Le Kremlin-Bicetre, Val-de-Marne, France, 94275
Germany, Baden-Wurttemberg	Heidelberg, Baden-Wurttemberg, Germany, 69126
Germany, Bayern	Wuerzburg, Bayern, Germany, 97074
Germany, Hessen	Gießen, Hessen, Germany, 35392
Germany, Niedersachsen	Hannover, Niedersachsen, Germany, 30625
Germany, Sachsen	Dresden, Sachsen, Germany, 01307
Germany, Sachsen	Leipzig, Sachsen, Germany, 04103
Greece, Thessaloniki	Thessaloniki, Greece, 54636
Israel, N/A	Beer Sheva, N/A, Israel, 8410101
Israel, N/A	Haifa, N/A, Israel, 3109601
Israel, N/A	Holon, N/A, Israel, 5810000
Israel, N/A	Jerusalem, N/A, Israel, 9103102
Israel, N/A	Petah Tikva, N/A, Israel, 4941492
Italy, Campania	naples, Campania, Italy, 80100
Italy, Lazio	Roma, Lazio, Italy, 00161
Italy, Milano	Milano, Italy, 20138
Italy, Monza e Brianza	Monza, Monza e Brianza, Italy, 20900
Italy, Pavia	Pavia, Italy, 27100
Mexico, Mexico	Huixquilucan, Mexico, Mexico, 52763
Mexico, Mexico	Mexico D.F, Mexico, Mexico, 14080
Mexico, Veracruz	Xalapa, Veracruz, Mexico, 91193
New Zealand, Auckland	Auckland, New Zealand, 1051
New Zealand, Canterbury	Christchurch, Canterbury, New Zealand, 8011
Poland, Dolnoslaskie	Walbrzych, Dolnoslaskie, Poland, 58-309
Poland, Lubelskie	Lublin, Lubelskie, Poland, 20-954
Poland, Malopolskie	Krakow, Malopolskie, Poland, 31-202
Russian Federation, Kemerovskaya oblast	Kemerovo, Kemerovskaya oblast, Russian Federation, 650002
Russian Federation, Sankt-Peterburg	Saint Petersburg, Sankt-Peterburg, Russian Federation, 197341
Sweden, Uppsala lan	Uppsala, Uppsala lan, Sweden, 751 85
Sweden, Vastra Gotalands lan	Gothenburg, Vastra Gotalands lan, Sweden, 413 45
Turkey, Ankara	Ankara, Turkey, 06100
Turkey, Antalya	Antalya, Turkey, 07059
Turkey, Eskisehir	Eskisehir, Turkey, 26040
Turkey, Istanbul	Istanbul, Turkey, 34096
Turkey, Istanbul	Istanbul, Turkey, 34899
Turkey, Istanbul	Istanbul, Turkey, 34390
Turkey, Izmir	Bornova, Izmir, Turkey, 35100
Turkey, Izmir	Izmir, Turkey, 35330
United Kingdom, Glasgow City	Glasgow, Glasgow City, United Kingdom, G81 4DY
United Kingdom, London, City of	London, London, City of, United Kingdom, W12 0HS
United Kingdom, London, City of	London, London, City of, United Kingdom, SW3 6NP
United Kingdom, Newcastle upon Tyne	Newcastle-upon-Tyne, Newcastle upon Tyne, United Kingdom, NE7 7DN
United States, CA	La Jolla, CA, United States, 92037-7381
United States, CA	Sacramento, CA, United States, 95817
United States, CA	San Francisco, CA, United States, 94143
United States, CO	Aurora, CO, United States, 80045
United States, CO	Greeley, CO, United States, 80631
United States, DC	Washington, DC, United States, 20007
United States, FL	Miami, FL, United States, 33136
United States, FL	Orlando, FL, United States, 32803
United States, FL	Tampa, FL, United States, 33606
United States, IA	Iowa City, IA, United States, 52242
United States, IN	Indianapolis, IN, United States, 46202-1239
United States, KS	Kansas City, KS, United States, 66160
United States, KY	Lexington, KY, United States, 40536
United States, KY	Louisville, KY, United States, 40202
United States, MD	Baltimore, MD, United States, 21201
United States, MO	St. Louis, MO, United States, 63110
United States, NC	Chapel Hill, NC, United States, 27514
United States, NE	Omaha, NE, United States, 68198
United States, NM	Albuquerque, NM, United States, 87131
United States, SC	Anderson, SC, United States, 29621
United States, TN	Knoxville, TN, United States, 37934
United States, TX	Dallas, TX, United States, 75390
United States, TX	Houston, TX, United States, 77030
United States, TX	HOUSTON, TX, United States, 77030
United States, VA	Norfolk, VA, United States, 23507
United States, WV	Morgantown, WV, United States, 26506