| Trial Identifier: | 3475-B49 |
| Sponsor: | MSD |
| Start Date: | June 2021 |
| Primary Completion Date: | March 2025 |
| Study Completion Date: | March 2025 |
| Condition: | Breast Cancer |
For questions about your Trial Results Summary, please see Sponsor contact section within your Trial Results Summary.
| Language | Description |
| Protocol Plain Language Summary - English | |
| Protocol Plain Language Summary – English |
| Country | Location |
|---|---|
| Argentina, Buenos Aires | Berazategui, Buenos Aires, Argentina, 1884 |
| Argentina, Buenos Aires | Ciudad autónoma de Buenos Aires, Buenos Aires, Argentina, 1280 |
| Argentina, Buenos Aires | Mar del Plata, Buenos Aires, Argentina, B7600FZO |
| Argentina, CABA | Buenos Aires, CABA, Argentina, C1431FWO |
| Argentina, CABA | Buenos Aires, CABA, Argentina, C1118AAT |
| Argentina, Cordoba | Cordoba, Argentina, 5000 |
| Argentina, Cordoba | CORDOBA, Cordoba, Argentina, X5008HHW |
| Argentina, San Juan | San Juan, Argentina, J5400EBB |
| Argentina, Santa Fe | Rosario, Santa Fe, Argentina, S2000KZE |
| Argentina, Santa Fe | Rosario, Santa Fe, Argentina, S2000DSV |
| Argentina, Santa Fe | Rosario, Santa Fe, Argentina, 2000 |
| Australia, New South Wales | Macquarie Park, New South Wales, Australia, 2109 |
| Australia, New South Wales | Westmead, New South Wales, Australia, 2145 |
| Australia, Victoria | Frankston, Victoria, Australia, 3199 |
| Australia, Western Australia | Nedlands, Western Australia, Australia, 6009 |
| Austria, Niederosterreich | Wiener Neustadt, Niederosterreich, Austria, 2700 |
| Austria, Salzburg | Salzburg, Austria, 5020 |
| Austria, Steiermark | Graz, Steiermark, Austria, 8036 |
| Austria, Tirol | Innsbruck, Tirol, Austria, 6020 |
| Austria, Wien | Vienna, Wien, Austria, 1090 |
| Brazil, Pernambuco | Recife, Pernambuco, Brazil, 50040-000 |
| Brazil, Rio de Janeiro | Rio de Janeiro, Brazil, 20775-001 |
| Brazil, Rio de Janeiro | Rio de Janeiro, Brazil, 20560121 |
| Brazil, Rio Grande do Sul | Santa Cruz do Sul, Rio Grande do Sul, Brazil, 96830-180 |
| Brazil, Santa Catarina | Blumenau, Santa Catarina, Brazil, 89010-340 |
| Brazil, Santa Catarina | Florianópolis, Santa Catarina, Brazil, 88020210 |
| Canada, AB | Calgary, AB, Canada, T2N 4N2 |
| Canada, ON | Toronto, ON, Canada, M5G 2M9 |
| Canada, ON | Toronto, ON, Canada, M2K 1E1 |
| Canada, QC | Montreal, QC, Canada, H3T 1E2 |
| Canada, QC | Montréal, QC, Canada, H2X 3E4 |
| Canada, QC | Quebec City, QC, Canada, G1S 4L8 |
| Canada, QC | Trois-Rivières, QC, Canada, G8Z 3R9 |
| Chile, Araucania | Temuco, Araucania, Chile, 4800827 |
| Chile, Region M. de Santiago | Santiago, Region M. de Santiago, Chile, 8420383 |
| Chile, Region M. de Santiago | Santiago, Region M. de Santiago, Chile, 8380455 |
| Chile, Region M. de Santiago | Santiago, Region M. de Santiago, Chile, 7510032 |
| Chile, Region M. de Santiago | Santiago, Region M. de Santiago, Chile, 7500921 |
| Chile, Region M. de Santiago | Santiago, Region M. de Santiago, Chile, 7650018 |
| China, Anhui | Hefei, Anhui, China, 230031 |
| China, Beijing | Beijing, China, 100142 |
| China, Beijing | Beijing, China, 100730 |
| China, Beijing | Beijing, China, 100021 |
| China, Fujian | Xiamen, Fujian, China, 361003 |
| China, Guangdong | Foshan, Guangdong, China, 528041 |
| China, Guangdong | Guangzhou, Guangdong, China, 510060 |
| China, Guangdong | Guangzhou, Guangdong, China, 510289 |
| China, Guangdong | Shenzhen, Guangdong, China, 518036 |
| China, Guangxi | Nanning, Guangxi, China, 530021 |
| China, Henan | Zhengzhou, Henan, China, 450003 |
| China, Hubei | Wuhan, Hubei, China, 430022 |
| China, Hunan | Changsha, Hunan, China, 410008 |
| China, Hunan | Changsha, Hunan, China, 410013 |
| China, Jiangsu | Nanjing, Jiangsu, China, 210036 |
| China, Jiangxi | Nanchang, Jiangxi, China, 330009 |
| China, Jilin | Changchun, Jilin, China, 130012 |
| China, Shaanxi | xi'an, Shaanxi, China, 710061 |
| China, Shandong | Jinan, Shandong, China, 250117 |
| China, Shanghai | shanghai, Shanghai, China, 200120 |
| China, Shanghai | Shanghai, China, 200032 |
| China, Sichuan | Cheng Du, Sichuan, China, 610041 |
| China, Tianjin | Tianjin, China, 300060 |
| China, Xinjiang | Urumqi, Xinjiang, China, 830000 |
| China, Zhejiang | hangzhou, Zhejiang, China, 310022 |
| China, Zhejiang | Linhai, Zhejiang, China, 317000 |
| China, Zhejiang | Wenzhou, Zhejiang, China, 325000 |
| Colombia, Antioquia | Medellín, Antioquia, Colombia, 050021435 |
| Colombia, Antioquia | Medellín, Antioquia, Colombia, 050024 |
| Colombia, Atlantico | Barranquilla, Atlantico, Colombia, 080020 |
| Colombia, Cesar | Valledupar, Cesar, Colombia, 200001 |
| Colombia, Cordoba | Montería, Cordoba, Colombia, 230002 |
| Colombia, Distrito Capital de Bogota | bogota, Distrito Capital de Bogota, Colombia, 111321 |
| France, Bouches-du-Rhone | Marseille, Bouches-du-Rhone, France, 13009 |
| France, Calvados | Caen, Calvados, France, 14076 |
| France, Franche-Comte | Besançon, Franche-Comte, France, 25000 |
| France, Haute-Garonne | TOULOUSE, Haute-Garonne, France, 31059 |
| France, Ile-de-France | Villejuif, Ile-de-France, France, 94805 |
| France, Languedoc-Roussillon | Montpellier, Languedoc-Roussillon, France, 34070 |
| France, Loire-Atlantique | Saint Herblain, Loire-Atlantique, France, 44805 |
| France, Maine-et-Loire | ANGERS cedex 02, Maine-et-Loire, France, 49055 |
| France, Nord | Lille, Nord, France, 59000 |
| France, Paris | Paris, France, 75248 |
| France, Puy-de-Dome | Clermont-Ferrand, Puy-de-Dome, France, 63011 |
| France, Rhone-Alpes | Lyon, Rhone-Alpes, France, 69008 |
| France, Seine-Maritime | Rouen, Seine-Maritime, France, 76038 |
| France, Vienne | Poitiers, Vienne, France, 86021 |
| Germany, Bayern | Erlangen, Bayern, Germany, 91054 |
| Germany, Berlin | Berlin, Germany, 10967 |
| Germany, Nordrhein-Westfalen | Bonn, Nordrhein-Westfalen, Germany, 53111 |
| Germany, Nordrhein-Westfalen | Düsseldorf, Nordrhein-Westfalen, Germany, 40225 |
| Germany, Nordrhein-Westfalen | Essen, Nordrhein-Westfalen, Germany, 45136 |
| Germany, Sachsen | Dresden, Sachsen, Germany, 01307 |
| Greece, Attiki | Athens, Attiki, Greece, 115 28 |
| Greece, Attiki | Athens, Attiki, Greece, 115 26 |
| Greece, Attiki | Marousi, Attiki, Greece, 151 23 |
| Greece, Irakleio | Heraklion, Irakleio, Greece, 715 00 |
| Greece, Thessaloniki | Thessaloniki, Greece, 546 45 |
| Guatemala, Guatemala | Guatemala, Guatemala, 01010 |
| Guatemala, Quetzaltenango | QUETZALTENANGO, Quetzaltenango, Guatemala, 09002 |
| Hungary, Bacs-Kiskun | Kecskemét, Bacs-Kiskun, Hungary, 6000 |
| Hungary, Baranya | Pécs, Baranya, Hungary, 7624 |
| Hungary, Csongrad | Szeged, Csongrad, Hungary, 6725 |
| Ireland, Dublin | Dublin, Ireland, D4 YN63 |
| Ireland, Dublin | Dublin, Ireland, D08 E9P6 |
| Israel, N/A | Ashdod, N/A, Israel, 7747629 |
| Israel, N/A | Be'er Sheva, N/A, Israel, 8400000 |
| Israel, N/A | Haifa, N/A, Israel, 3339419 |
| Israel, N/A | Ramat Gan, N/A, Israel, 5265601 |
| Israel, N/A | Tel Aviv, N/A, Israel, 6423906 |
| Italy, Bari | Bari, Italy, 70124 |
| Italy, Catania | Catania, Italy, 95126 |
| Italy, Lazio | Roma, Lazio, Italy, 00168 |
| Italy, Lombardia | Milano, Lombardia, Italy, 20132 |
| Italy, Lombardia | Monza, Lombardia, Italy, 20900 |
| Italy, Milano | Milano, Italy, 20141 |
| Italy, Milano | Rozzano, Milano, Italy, 20089 |
| Italy, Napoli | Napoli, Italy, 80131 |
| Italy, Padova | Padova, Italy, 35128 |
| Japan, Chiba | Chiba, Japan, 260-8677 |
| Japan, Fukuoka | Fukuoka, Japan, 811-1395 |
| Japan, Fukushima | Fukushima, Japan, 960-1295 |
| Japan, Hyogo | Nishinomiya, Hyogo, Japan, 663-8501 |
| Japan, Kanagawa | Kawasaki, Kanagawa, Japan, 216-8511 |
| Japan, Kanagawa | Sagamihara, Kanagawa, Japan, 252-0375 |
| Japan, Kumamoto | Kumamoto, Japan, 860-8556 |
| Japan, Osaka | Suita, Osaka, Japan, 565-0871 |
| Japan, Saitama | Hidaka-city, Saitama, Japan, 350-1298 |
| Japan, Tokyo | Shinjuku-ku, Tokyo, Japan, 160-0023 |
| Japan, Tokyo | Tokyo, Japan, 104-8560 |
| Japan, Tokyo | Tokyo, Japan, 113-8431 |
| Korea, Republic of, Kyonggi-do | Goyang-si, Kyonggi-do, Korea, Republic of, 10408 |
| Korea, Republic of, Kyonggi-do | Seongnam, Kyonggi-do, Korea, Republic of, 13620 |
| Korea, Republic of, Seoul | Seoul, Korea, Republic of, 03722 |
| Korea, Republic of, Seoul | Seoul, Korea, Republic of, 05505 |
| Korea, Republic of, Seoul | Seoul, Korea, Republic of, 03080 |
| Korea, Republic of, Seoul | Seoul, Korea, Republic of, 06351 |
| Malaysia, Kuala Lumpur | Kuala Lumpur, Malaysia, 59100 |
| Malaysia, Kuala Lumpur | Kuala Lumpur, Malaysia, 50586 |
| Malaysia, Kuala Lumpur | Lembah Pantai, Kuala Lumpur, Malaysia, 59100 |
| Malaysia, Pulau Pinang | George Town, Pulau Pinang, Malaysia, 10990 |
| Malaysia, Sarawak | Kuching, Sarawak, Malaysia, 93586 |
| Mexico, Chihuahua | CHIHUAHUA, Chihuahua, Mexico, 31000 |
| Mexico, Distrito Federal | México, Distrito Federal, Mexico, 04739 |
| Mexico, Jalisco | Guadalajara, Jalisco, Mexico, 44280 |
| Mexico, Nuevo Leon | Monterrey, Nuevo Leon, Mexico, 64460 |
| Mexico, Oaxaca | Oaxaca, Mexico, 68020 |
| Netherlands, Gelderland | Nijmegen, Gelderland, Netherlands, 6525 GA |
| Netherlands, Limburg | Maastricht, Limburg, Netherlands, 6229 HX |
| Netherlands, Noord-Brabant | Den Bosch, Noord-Brabant, Netherlands, 5223 GZ |
| Netherlands, Noord-Brabant | Tilburg, Noord-Brabant, Netherlands, 5022 GC |
| Netherlands, Noord-Holland | Amsterdam, Noord-Holland, Netherlands, 1066 CX |
| Netherlands, Utrecht | Amersfoort, Utrecht, Netherlands, 3813TZ |
| Netherlands, Zuid-Holland | Leiden, Zuid-Holland, Netherlands, 2333 ZA |
| Netherlands, Zuid-Holland | Leidschendam, Zuid-Holland, Netherlands, 2501 ck |
| Netherlands, Zuid-Holland | Schiedam, Zuid-Holland, Netherlands, 3118JH |
| Philippines, National Capital Region | Quezon City, National Capital Region, Philippines, 1500 |
| Philippines, National Capital Region | San Juan, National Capital Region, Philippines, 1502 |
| Poland, Kujawsko-pomorskie | Bydgoszcz, Kujawsko-pomorskie, Poland, 85-796 |
| Poland, Malopolskie | Krakow, Malopolskie, Poland, 30-727 |
| Poland, Mazowieckie | Siedlce, Mazowieckie, Poland, 08-110 |
| Poland, Mazowieckie | Warsaw, Mazowieckie, Poland, 04-125 |
| Poland, Mazowieckie | Warszawa, Mazowieckie, Poland, 02-781 |
| Poland, Mazowieckie | Warszawa, Mazowieckie, Poland, 04-141 |
| Poland, Mazowieckie | Warszawa, Mazowieckie, Poland, 01-748 |
| Poland, Mazowieckie | Wieliszew, Mazowieckie, Poland, 05-135 |
| Poland, Podkarpackie | Przemysl, Podkarpackie, Poland, 37-700 |
| Poland, Podlaskie | Bialystok, Podlaskie, Poland, 15-027 |
| Poland, Slaskie | Gliwice, Slaskie, Poland, 44-101 |
| Poland, Zachodniopomorskie | Koszalin, Zachodniopomorskie, Poland, 75-581 |
| Portugal, Lisboa | Lisbon, Lisboa, Portugal, 1400-038 |
| Portugal, Lisboa | Lisbon, Lisboa, Portugal, 1649-035 |
| Portugal, Porto | Matosinhos, Porto, Portugal, 4464-513 |
| Portugal, Porto | Porto, Portugal, 4099-001 |
| Portugal, Porto | Porto, Portugal, 4200-072 |
| Romania, Cluj | Cluj-Napoca, Cluj, Romania, 400015 |
| Romania, Dolj | Craiova, Dolj, Romania, 200542 |
| Romania, Maramures | Baia Mare, Maramures, Romania, 430291 |
| Romania, Suceava | Suceava, Romania, 720214 |
| Russian Federation, Arkhangel skaya oblast | Arkhangelsk, Arkhangel skaya oblast, Russian Federation, 163045 |
| Russian Federation, Moskovskaya oblast | Podolsk, Moskovskaya oblast, Russian Federation, 142110 |
| Russian Federation, Moskva | Moscow, Moskva, Russian Federation, 111123 |
| Russian Federation, Moskva | Moscow, Moskva, Russian Federation, 121359 |
| Russian Federation, Moskva | Moscow, Moskva, Russian Federation, 115478 |
| Russian Federation, Nizhegorodskaya oblast | Nizhniy Novgorod, Nizhegorodskaya oblast, Russian Federation, 603081 |
| Russian Federation, Ryazanskaya oblast | Ryazan, Ryazanskaya oblast, Russian Federation, 390046 |
| Russian Federation, Sankt-Peterburg | Saint Petersburg, Sankt-Peterburg, Russian Federation, 197758 |
| Russian Federation, Sankt-Peterburg | St. Petersburg, Sankt-Peterburg, Russian Federation, 194017 |
| Spain, Cataluna | Barcelona, Cataluna, Spain, 08023 |
| Spain, Madrid | Pozuelo de Alarcon, Madrid, Spain, 28223 |
| Spain, Madrid, Comunidad de | Madrid, Madrid, Comunidad de, Spain, 28034 |
| Spain, Madrid, Comunidad de | Madrid, Madrid, Comunidad de, Spain, 28007 |
| Spain, Valenciana, Comunitat | Valencia, Valenciana, Comunitat, Spain, 46009 |
| Sweden, Stockholms lan | Stockholm, Stockholms lan, Sweden, 171 76 |
| Sweden, Vastra Gotalands lan | Borås, Vastra Gotalands lan, Sweden, 501 82 |
| Turkey, Adana | Adana, Turkey, 01250 |
| Turkey, Ankara | Ankara, Turkey, 06230 |
| Turkey, Ankara | Ankara, Turkey, 06520 |
| Turkey, Ankara | Ankara, Turkey, 06560 |
| Turkey, Ankara | Ankara, Turkey, 06800 |
| Turkey, Antalya | Antalya, Turkey, 07059 |
| Turkey, Istanbul | Istanbul, Turkey, 34668 |
| Turkey, Istanbul | Istanbul, Turkey, 34722 |
| Turkey, Izmir | Bornova, Izmir, Turkey, 35100 |
| Turkey, Izmir | Izmir, Karsiyaka, Izmir, Turkey, 009035575 |
| Turkey, Malatya | Malatya, Turkey, 44280 |
| United Kingdom, Cornwall | Truro, Cornwall, United Kingdom, TR1 3LJ |
| United Kingdom, England | Leicester, England, United Kingdom |
| United Kingdom, England | London, England, United Kingdom, EC1A 7BE |
| United Kingdom, England | Manchester, England, United Kingdom, M20 4BX |
| United Kingdom, Lancashire | BLACKPOOL, Lancashire, United Kingdom, FY38NR |
| United Kingdom, London, City of | London, London, City of, United Kingdom, SE1 9RT |
| United Kingdom, London, City of | Londonderry, London, City of, United Kingdom, BT47 6SB |
| United States, AL | Birmingham, AL, United States, 35294-3300 |
| United States, AZ | Tucson, AZ, United States, 85711 |
| United States, CA | Monterey, CA, United States, 93940 |
| United States, CA | San Francisco, CA, United States, 94158 |
| United States, DC | Washington, DC, United States, 20007 |
| United States, DC | Washington, DC, United States, 20010 |
| United States, FL | Jacksonville, FL, United States, 32207 |
| United States, FL | Miami, FL, United States, 33176 |
| United States, FL | Plantation, FL, United States, 33324 |
| United States, GA | Athens, GA, United States, 30607 |
| United States, GA | Marietta, GA, United States, 30060 |
| United States, IA | Ames, IA, United States, 50010-3014 |
| United States, IL | Chicago, IL, United States, 60612 |
| United States, IL | Elmhurst, IL, United States, 60126 |
| United States, IL | Naperville, IL, United States, 60540 |
| United States, IL | Plainfield, IL, United States, 60585 |
| United States, IL | Skokie, IL, United States, 60077 |
| United States, IN | Fort Wayne, IN, United States, 46845 |
| United States, LA | Shreveport, LA, United States, 71103 |
| United States, LA | Shreveport, LA, United States, 71105 |
| United States, MA | Worcester, MA, United States, 01655 |
| United States, MD | Baltimore, MD, United States, 21204 |
| United States, MD | Baltimore, MD, United States, 21237 |
| United States, MD | Baltimore, MD, United States, 21239 |
| United States, ME | Scarborough, ME, United States, 04074 |
| United States, MI | Detroit, MI, United States, 48202 |
| United States, NC | Cary, NC, United States, 27518 |
| United States, ND | Fargo, ND, United States, 58102 |
| United States, NE | Omaha, NE, United States, 68130 |
| United States, NY | Johnson City, NY, United States, 13790 |
| United States, NY | Nyack, NY, United States, 10960 |
| United States, OR | Portland, OR, United States, 97213 |
| United States, OR | Portland, OR, United States, 97239-3011 |
| United States, SC | Greenville, SC, United States, 29607 |
| United States, SD | Sioux falls, SD, United States, 57104 |
| United States, TN | Knoxville, TN, United States, 37920 |
| United States, VA | Midlothian, VA, United States, 23114 |
| United States, WA | Kennewick, WA, United States, 99336 |
| United States, WA | Spokane, WA, United States, 99208 |
| United States, WA | Tacoma, WA, United States, 98405 |
| United States, WA | Yakima, WA, United States, 98902 |
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